Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus

Abstract Antibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic...

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Autores principales:	D. P. Neveling, L. van Emmenes, J. J. Ahire, E. Pieterse, C. Smith, L. M. T. Dicks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7041182d964b4e8481b6a6175a1392e4
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spelling	oai:doaj.org-article:7041182d964b4e8481b6a6175a1392e42021-12-02T15:05:54ZSafety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus10.1038/s41598-017-12866-72045-2322https://doaj.org/article/7041182d964b4e8481b6a6175a1392e42017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-12866-7https://doaj.org/toc/2045-2322Abstract Antibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic or a combination of sulphadiazine, colistin and trimethoprim, whereas the control group received standard feed. The villi of immature broilers (19 days old) administered antibiotics had a larger surface area and their lymphocyte and basophil counts were higher compared to broilers from the probiotic and control groups. The cecal microbiomes of mature broilers (29 days old) that received probiotics had higher levels of Enterobacteriaceae, but lower numbers of Clostridiales, Brucellaceae, Synergistaceae, Erysipelotrichaceae and Coriobacteriaceae compared to the antibiotic-treated group. A decline in the bioluminescence of Listeria monocytogenes observed for broilers on probiotics suggested that the probiotic may be used to control bacterial infections. No significant differences in total red blood cell, haemoglobin and haematocrit content, and mean values for corpuscular volume, corpuscular haemoglobin and corpuscular haemoglobin numbers were recorded amongst broilers from the different treatment groups. This study provides valuable information on the health and performance of broilers when administered probiotics and antibiotics as additives.D. P. NevelingL. van EmmenesJ. J. AhireE. PieterseC. SmithL. M. T. DicksNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. P. Neveling L. van Emmenes J. J. Ahire E. Pieterse C. Smith L. M. T. Dicks Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus
description	Abstract Antibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic or a combination of sulphadiazine, colistin and trimethoprim, whereas the control group received standard feed. The villi of immature broilers (19 days old) administered antibiotics had a larger surface area and their lymphocyte and basophil counts were higher compared to broilers from the probiotic and control groups. The cecal microbiomes of mature broilers (29 days old) that received probiotics had higher levels of Enterobacteriaceae, but lower numbers of Clostridiales, Brucellaceae, Synergistaceae, Erysipelotrichaceae and Coriobacteriaceae compared to the antibiotic-treated group. A decline in the bioluminescence of Listeria monocytogenes observed for broilers on probiotics suggested that the probiotic may be used to control bacterial infections. No significant differences in total red blood cell, haemoglobin and haematocrit content, and mean values for corpuscular volume, corpuscular haemoglobin and corpuscular haemoglobin numbers were recorded amongst broilers from the different treatment groups. This study provides valuable information on the health and performance of broilers when administered probiotics and antibiotics as additives.
format	article
author	D. P. Neveling L. van Emmenes J. J. Ahire E. Pieterse C. Smith L. M. T. Dicks
author_facet	D. P. Neveling L. van Emmenes J. J. Ahire E. Pieterse C. Smith L. M. T. Dicks
author_sort	D. P. Neveling
title	Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus
title_short	Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus
title_full	Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus
title_fullStr	Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus
title_full_unstemmed	Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus
title_sort	safety assessment of antibiotic and probiotic feed additives for gallus gallus domesticus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7041182d964b4e8481b6a6175a1392e4
work_keys_str_mv	AT dpneveling safetyassessmentofantibioticandprobioticfeedadditivesforgallusgallusdomesticus AT lvanemmenes safetyassessmentofantibioticandprobioticfeedadditivesforgallusgallusdomesticus AT jjahire safetyassessmentofantibioticandprobioticfeedadditivesforgallusgallusdomesticus AT epieterse safetyassessmentofantibioticandprobioticfeedadditivesforgallusgallusdomesticus AT csmith safetyassessmentofantibioticandprobioticfeedadditivesforgallusgallusdomesticus AT lmtdicks safetyassessmentofantibioticandprobioticfeedadditivesforgallusgallusdomesticus
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Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus

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