Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men

Abstract Individual variation in the age of pubertal onset is linked to physical and mental health, yet the factors underlying this variation are poorly understood. Life history theory predicts that individuals at higher risk of mortality due to extrinsic causes such as infectious disease should sex...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Steven Arnocky, Carolyn Hodges-Simeon, Adam C. Davis, Riley Desmarais, Anna Greenshields, Robert Liwski, Ellen E. Quillen, Rodrigo Cardenas, S. Marc Breedlove, David Puts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7042a361f7004d99a405b53fcf5b95c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7042a361f7004d99a405b53fcf5b95c5
record_format	dspace
spelling	oai:doaj.org-article:7042a361f7004d99a405b53fcf5b95c52021-12-02T18:37:10ZHeterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men10.1038/s41598-021-99334-52045-2322https://doaj.org/article/7042a361f7004d99a405b53fcf5b95c52021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99334-5https://doaj.org/toc/2045-2322Abstract Individual variation in the age of pubertal onset is linked to physical and mental health, yet the factors underlying this variation are poorly understood. Life history theory predicts that individuals at higher risk of mortality due to extrinsic causes such as infectious disease should sexually mature and reproduce earlier, whereas those at lower risk can delay puberty and continue to invest resources in somatic growth. We examined relationships between a genetic predictor of infectious disease resistance, heterozygosity of the major histocompatibility complex (MHC), referred to as the human leukocyte antigen (HLA) gene in humans, and self-reported pubertal timing. In a combined sample of men from Canada (n = 137) and the United States (n = 43), MHC heterozygosity predicted later self-reported pubertal development. These findings suggest a genetic trade-off between immunocompetence and sexual maturation in human males.Steven ArnockyCarolyn Hodges-SimeonAdam C. DavisRiley DesmaraisAnna GreenshieldsRobert LiwskiEllen E. QuillenRodrigo CardenasS. Marc BreedloveDavid PutsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Steven Arnocky Carolyn Hodges-Simeon Adam C. Davis Riley Desmarais Anna Greenshields Robert Liwski Ellen E. Quillen Rodrigo Cardenas S. Marc Breedlove David Puts Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
description	Abstract Individual variation in the age of pubertal onset is linked to physical and mental health, yet the factors underlying this variation are poorly understood. Life history theory predicts that individuals at higher risk of mortality due to extrinsic causes such as infectious disease should sexually mature and reproduce earlier, whereas those at lower risk can delay puberty and continue to invest resources in somatic growth. We examined relationships between a genetic predictor of infectious disease resistance, heterozygosity of the major histocompatibility complex (MHC), referred to as the human leukocyte antigen (HLA) gene in humans, and self-reported pubertal timing. In a combined sample of men from Canada (n = 137) and the United States (n = 43), MHC heterozygosity predicted later self-reported pubertal development. These findings suggest a genetic trade-off between immunocompetence and sexual maturation in human males.
format	article
author	Steven Arnocky Carolyn Hodges-Simeon Adam C. Davis Riley Desmarais Anna Greenshields Robert Liwski Ellen E. Quillen Rodrigo Cardenas S. Marc Breedlove David Puts
author_facet	Steven Arnocky Carolyn Hodges-Simeon Adam C. Davis Riley Desmarais Anna Greenshields Robert Liwski Ellen E. Quillen Rodrigo Cardenas S. Marc Breedlove David Puts
author_sort	Steven Arnocky
title	Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
title_short	Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
title_full	Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
title_fullStr	Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
title_full_unstemmed	Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
title_sort	heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7042a361f7004d99a405b53fcf5b95c5
work_keys_str_mv	AT stevenarnocky heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT carolynhodgessimeon heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT adamcdavis heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT rileydesmarais heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT annagreenshields heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT robertliwski heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT ellenequillen heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT rodrigocardenas heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT smarcbreedlove heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen AT davidputs heterozygosityofthemajorhistocompatibilitycomplexpredictslaterselfreportedpubertalmaturationinmen
_version_	1718377804339347456

Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men

Ejemplares similares