Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Shih-Hsiang Liao,1 Chia-Hung Liu,2 Bishnu Prasad Bastakoti,3 Norihiro Suzuki,7 Yung Chang,4 Yusuke Yamauchi,3 Feng-Huei Lin,5,6 Kevin C-W Wu1,6 1Department of Chemical Engineering, National Taiwan University No 1, Taipei, 2Department of Urology, Taipei Medical University-Shuang Ho Hospital, New Tai...

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Autores principales:	Liao SH, Liu CH, Bastakoti BP, Suzuki N, Chang Y, Yamauchi Y, Lin FH, Wu KCW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7042fa1076a24f9f83f80cefdcc16646
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spelling	oai:doaj.org-article:7042fa1076a24f9f83f80cefdcc166462021-12-02T00:59:55ZFunctionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia1178-2013https://doaj.org/article/7042fa1076a24f9f83f80cefdcc166462015-05-01T00:00:00Zhttp://www.dovepress.com/functionalized-magnetic-iron-oxidealginate-core-shell-nanoparticles-fo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shih-Hsiang Liao,1 Chia-Hung Liu,2 Bishnu Prasad Bastakoti,3 Norihiro Suzuki,7 Yung Chang,4 Yusuke Yamauchi,3 Feng-Huei Lin,5,6 Kevin C-W Wu1,6 1Department of Chemical Engineering, National Taiwan University No 1, Taipei, 2Department of Urology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; 3National Institute for Materials Science, Ibaraki, Japan; 4R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Taoyua, 5Institute of Biomedical Engineering, National Taiwan University No 1, Taipei City, 6Division of Medical Engineering Research, National Health Research Institutes, Miaoli County, Taiwan, 7International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan Abstract: Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems. Keywords: hyperthermia, iron oxide, alginate, pre-gel, targeting Liao SHLiu CHBastakoti BPSuzuki NChang YYamauchi YLin FHWu KCWDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3315-3328 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Liao SH Liu CH Bastakoti BP Suzuki N Chang Y Yamauchi Y Lin FH Wu KCW Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
description	Shih-Hsiang Liao,1 Chia-Hung Liu,2 Bishnu Prasad Bastakoti,3 Norihiro Suzuki,7 Yung Chang,4 Yusuke Yamauchi,3 Feng-Huei Lin,5,6 Kevin C-W Wu1,6 1Department of Chemical Engineering, National Taiwan University No 1, Taipei, 2Department of Urology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; 3National Institute for Materials Science, Ibaraki, Japan; 4R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Taoyua, 5Institute of Biomedical Engineering, National Taiwan University No 1, Taipei City, 6Division of Medical Engineering Research, National Health Research Institutes, Miaoli County, Taiwan, 7International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan Abstract: Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems. Keywords: hyperthermia, iron oxide, alginate, pre-gel, targeting
format	article
author	Liao SH Liu CH Bastakoti BP Suzuki N Chang Y Yamauchi Y Lin FH Wu KCW
author_facet	Liao SH Liu CH Bastakoti BP Suzuki N Chang Y Yamauchi Y Lin FH Wu KCW
author_sort	Liao SH
title	Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
title_short	Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
title_full	Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
title_fullStr	Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
title_full_unstemmed	Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
title_sort	functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/7042fa1076a24f9f83f80cefdcc16646
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_version_	1718403391285100544

Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

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