ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS

Objective: To compare the outcome of intra-articular hyaluronic acid injection with oral non-steroidal antiinflammatory drugs in knee osteoarthritis in terms of mean pain score. Study Design: Randomized controlled trial. Place and Duration of Study: Outpatient orthopedics department of Combine...

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Autores principales:	Usman Aziz, Sara Iqbal, Tariq Aziz, Hina Kanwal Shafaat, Saira Jilani
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	osteoarthritis non-steroidal anti-inflammatory drugs intra-articular injections Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/70445f1caa714025bd6648f69b61ee1e
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spelling	oai:doaj.org-article:70445f1caa714025bd6648f69b61ee1e2021-11-12T06:43:35ZANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS0030-96482411-8842https://doaj.org/article/70445f1caa714025bd6648f69b61ee1e2019-04-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2744/2151https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare the outcome of intra-articular hyaluronic acid injection with oral non-steroidal antiinflammatory drugs in knee osteoarthritis in terms of mean pain score. Study Design: Randomized controlled trial. Place and Duration of Study: Outpatient orthopedics department of Combined Military Hospital, Rawalpindi from February 2015 to July 2016. Patients and Methods: A total of 60 patients with knee osteoarthritis were enrolled as per inclusion and exclusion criteria by non-probability consecutive sampling. Thirty patients were assigned to group “A” and were given intra-articular injection of hyaluronic acid 20 mg (2 ml) into the knee joint aseptically for five consecutive weeks. Group “B”, having thirty patients, was given oral non-steroidal anti-inflammatory drug Celecoxib 200mg/Naproxen 500mg twice daily after meals for twelve weeks. Outcome measure was mean pain score using visual analogue scale at twelve week follow-up. Results: Statistically significant improvement in mean pain score on visual analogue scale at twelve week followup was found in patients of group “A”, with improvement in score from 7.2 ± 0.92 at the start of the study to 5.6 ± 1.23 at twelve week follow-up (p<0.001). No statistically significant results were obtained in patients with group “B” having pain score on visual analogue scale of 7.4 ± 0.94 at the start of the study to 7.3 ± 0.95 at twelve week follow-up (p= 0.373). Conclusion: The use of intra-articular injection of hyaluronic acid in knee osteoarthritis potentially offers a significantly greater clinical improvement in terms of pain relief, especially in radiological grades 1 to 3. Nonsteroidal anti-inflammatory drugs, on the other hand, are of lower comparative efficacy in the treatment of knee osteoarthritis pain.Usman AzizSara IqbalTariq AzizHina Kanwal ShafaatSaira JilaniArmy Medical College Rawalpindiarticleosteoarthritisnon-steroidal anti-inflammatory drugsintra-articular injectionsMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 2, Pp 314-318 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis non-steroidal anti-inflammatory drugs intra-articular injections Medicine R Medicine (General) R5-920
spellingShingle	osteoarthritis non-steroidal anti-inflammatory drugs intra-articular injections Medicine R Medicine (General) R5-920 Usman Aziz Sara Iqbal Tariq Aziz Hina Kanwal Shafaat Saira Jilani ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS
description	Objective: To compare the outcome of intra-articular hyaluronic acid injection with oral non-steroidal antiinflammatory drugs in knee osteoarthritis in terms of mean pain score. Study Design: Randomized controlled trial. Place and Duration of Study: Outpatient orthopedics department of Combined Military Hospital, Rawalpindi from February 2015 to July 2016. Patients and Methods: A total of 60 patients with knee osteoarthritis were enrolled as per inclusion and exclusion criteria by non-probability consecutive sampling. Thirty patients were assigned to group “A” and were given intra-articular injection of hyaluronic acid 20 mg (2 ml) into the knee joint aseptically for five consecutive weeks. Group “B”, having thirty patients, was given oral non-steroidal anti-inflammatory drug Celecoxib 200mg/Naproxen 500mg twice daily after meals for twelve weeks. Outcome measure was mean pain score using visual analogue scale at twelve week follow-up. Results: Statistically significant improvement in mean pain score on visual analogue scale at twelve week followup was found in patients of group “A”, with improvement in score from 7.2 ± 0.92 at the start of the study to 5.6 ± 1.23 at twelve week follow-up (p<0.001). No statistically significant results were obtained in patients with group “B” having pain score on visual analogue scale of 7.4 ± 0.94 at the start of the study to 7.3 ± 0.95 at twelve week follow-up (p= 0.373). Conclusion: The use of intra-articular injection of hyaluronic acid in knee osteoarthritis potentially offers a significantly greater clinical improvement in terms of pain relief, especially in radiological grades 1 to 3. Nonsteroidal anti-inflammatory drugs, on the other hand, are of lower comparative efficacy in the treatment of knee osteoarthritis pain.
format	article
author	Usman Aziz Sara Iqbal Tariq Aziz Hina Kanwal Shafaat Saira Jilani
author_facet	Usman Aziz Sara Iqbal Tariq Aziz Hina Kanwal Shafaat Saira Jilani
author_sort	Usman Aziz
title	ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS
title_short	ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS
title_full	ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS
title_fullStr	ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS
title_full_unstemmed	ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS
title_sort	anti-inflammatory drugs in management of knee osteoarthritis
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/70445f1caa714025bd6648f69b61ee1e
work_keys_str_mv	AT usmanaziz antiinflammatorydrugsinmanagementofkneeosteoarthritis AT saraiqbal antiinflammatorydrugsinmanagementofkneeosteoarthritis AT tariqaziz antiinflammatorydrugsinmanagementofkneeosteoarthritis AT hinakanwalshafaat antiinflammatorydrugsinmanagementofkneeosteoarthritis AT sairajilani antiinflammatorydrugsinmanagementofkneeosteoarthritis
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ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS

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