Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder

Background: Psychosocial stress negatively affects the clinical course of bipolar disorder. Studies primarily focused on adults with bipolar disorder suggest the impact of stress is progressive, i.e., stress response sensitizes with age. Neural mechanisms underlying stress sensitization are unknown....

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Autores principales:	Vanessa Le, Dylan E. Kirsch, Valeria Tretyak, Wade Weber, Stephen M. Strakowski, Elizabeth T. C. Lippard
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bipolar disorder alcohol drinking cannabis stress-psychological magnetic resonance imaging (MRI) Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/7044f174072a4d83aca320faef2ceed3
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spelling	oai:doaj.org-article:7044f174072a4d83aca320faef2ceed32021-11-15T06:45:22ZRecent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder1664-064010.3389/fpsyt.2021.767309https://doaj.org/article/7044f174072a4d83aca320faef2ceed32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.767309/fullhttps://doaj.org/toc/1664-0640Background: Psychosocial stress negatively affects the clinical course of bipolar disorder. Studies primarily focused on adults with bipolar disorder suggest the impact of stress is progressive, i.e., stress response sensitizes with age. Neural mechanisms underlying stress sensitization are unknown. As stress-related mechanisms contribute to alcohol/substance use disorders, variation in stress response in youth with bipolar disorder may contribute to development of co-occurring alcohol/substance use disorders. This study investigated relations between psychosocial stress, amygdala reactivity, and alcohol and cannabis use in youth with bipolar disorder, compared to typically developing youth.Methods: Forty-two adolescents/young adults [19 with bipolar disorder, 23 typically developing, 71% female, agemean ± SD = 21 ± 2 years] completed the Perceived Stress Scale (PSS), Daily Drinking Questionnaire modified for heaviest drinking week, and a modified Montreal Imaging Stress functional MRI Task. Amygdala activation was measured for both the control and stress conditions. Main effects of group, condition, total PSS, and their interactions on amygdala activation were modeled. Relationships between amygdala response to acute stress with recent alcohol/cannabis use were investigated.Results: Greater perceived stress related to increased right amygdala activation in response to the stress, compared to control, condition in bipolar disorder, but not in typically developing youth (group × condition × PSS interaction, p = 0.02). Greater amygdala reactivity to acute stress correlated with greater quantity and frequency of alcohol use and frequency of cannabis use in bipolar disorder.Conclusion: Recent perceived stress is associated with changes in amygdala activation during acute stress with amygdala reactivity related to alcohol/cannabis use in youth with bipolar disorder.Vanessa LeDylan E. KirschDylan E. KirschDylan E. KirschValeria TretyakValeria TretyakValeria TretyakWade WeberStephen M. StrakowskiStephen M. StrakowskiStephen M. StrakowskiStephen M. StrakowskiElizabeth T. C. LippardElizabeth T. C. LippardElizabeth T. C. LippardElizabeth T. C. LippardElizabeth T. C. LippardFrontiers Media S.A.articlebipolar disorderalcohol drinkingcannabisstress-psychologicalmagnetic resonance imaging (MRI)PsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder alcohol drinking cannabis stress-psychological magnetic resonance imaging (MRI) Psychiatry RC435-571
spellingShingle	bipolar disorder alcohol drinking cannabis stress-psychological magnetic resonance imaging (MRI) Psychiatry RC435-571 Vanessa Le Dylan E. Kirsch Dylan E. Kirsch Dylan E. Kirsch Valeria Tretyak Valeria Tretyak Valeria Tretyak Wade Weber Stephen M. Strakowski Stephen M. Strakowski Stephen M. Strakowski Stephen M. Strakowski Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder
description	Background: Psychosocial stress negatively affects the clinical course of bipolar disorder. Studies primarily focused on adults with bipolar disorder suggest the impact of stress is progressive, i.e., stress response sensitizes with age. Neural mechanisms underlying stress sensitization are unknown. As stress-related mechanisms contribute to alcohol/substance use disorders, variation in stress response in youth with bipolar disorder may contribute to development of co-occurring alcohol/substance use disorders. This study investigated relations between psychosocial stress, amygdala reactivity, and alcohol and cannabis use in youth with bipolar disorder, compared to typically developing youth.Methods: Forty-two adolescents/young adults [19 with bipolar disorder, 23 typically developing, 71% female, agemean ± SD = 21 ± 2 years] completed the Perceived Stress Scale (PSS), Daily Drinking Questionnaire modified for heaviest drinking week, and a modified Montreal Imaging Stress functional MRI Task. Amygdala activation was measured for both the control and stress conditions. Main effects of group, condition, total PSS, and their interactions on amygdala activation were modeled. Relationships between amygdala response to acute stress with recent alcohol/cannabis use were investigated.Results: Greater perceived stress related to increased right amygdala activation in response to the stress, compared to control, condition in bipolar disorder, but not in typically developing youth (group × condition × PSS interaction, p = 0.02). Greater amygdala reactivity to acute stress correlated with greater quantity and frequency of alcohol use and frequency of cannabis use in bipolar disorder.Conclusion: Recent perceived stress is associated with changes in amygdala activation during acute stress with amygdala reactivity related to alcohol/cannabis use in youth with bipolar disorder.
format	article
author	Vanessa Le Dylan E. Kirsch Dylan E. Kirsch Dylan E. Kirsch Valeria Tretyak Valeria Tretyak Valeria Tretyak Wade Weber Stephen M. Strakowski Stephen M. Strakowski Stephen M. Strakowski Stephen M. Strakowski Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard
author_facet	Vanessa Le Dylan E. Kirsch Dylan E. Kirsch Dylan E. Kirsch Valeria Tretyak Valeria Tretyak Valeria Tretyak Wade Weber Stephen M. Strakowski Stephen M. Strakowski Stephen M. Strakowski Stephen M. Strakowski Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard Elizabeth T. C. Lippard
author_sort	Vanessa Le
title	Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder
title_short	Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder
title_full	Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder
title_fullStr	Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder
title_full_unstemmed	Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder
title_sort	recent perceived stress, amygdala reactivity to acute psychosocial stress, and alcohol and cannabis use in adolescents and young adults with bipolar disorder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7044f174072a4d83aca320faef2ceed3
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Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder

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