Diffusion-limited association of disordered protein by non-native electrostatic interactions

Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins which involves the formation of a transient complex (TC). Here authors use single-molecule FRET to show that the lifetime of TC for IDP binding is very long due to the stabilization by non-native electrostatic in...

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Autores principales:	Jae-Yeol Kim, Fanjie Meng, Janghyun Yoo, Hoi Sung Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70516a3454314676950dba1a16adcf2d
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spelling	oai:doaj.org-article:70516a3454314676950dba1a16adcf2d2021-12-02T14:39:25ZDiffusion-limited association of disordered protein by non-native electrostatic interactions10.1038/s41467-018-06866-y2041-1723https://doaj.org/article/70516a3454314676950dba1a16adcf2d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06866-yhttps://doaj.org/toc/2041-1723Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins which involves the formation of a transient complex (TC). Here authors use single-molecule FRET to show that the lifetime of TC for IDP binding is very long due to the stabilization by non-native electrostatic interactions, which makes fast association possible.Jae-Yeol KimFanjie MengJanghyun YooHoi Sung ChungNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jae-Yeol Kim Fanjie Meng Janghyun Yoo Hoi Sung Chung Diffusion-limited association of disordered protein by non-native electrostatic interactions
description	Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins which involves the formation of a transient complex (TC). Here authors use single-molecule FRET to show that the lifetime of TC for IDP binding is very long due to the stabilization by non-native electrostatic interactions, which makes fast association possible.
format	article
author	Jae-Yeol Kim Fanjie Meng Janghyun Yoo Hoi Sung Chung
author_facet	Jae-Yeol Kim Fanjie Meng Janghyun Yoo Hoi Sung Chung
author_sort	Jae-Yeol Kim
title	Diffusion-limited association of disordered protein by non-native electrostatic interactions
title_short	Diffusion-limited association of disordered protein by non-native electrostatic interactions
title_full	Diffusion-limited association of disordered protein by non-native electrostatic interactions
title_fullStr	Diffusion-limited association of disordered protein by non-native electrostatic interactions
title_full_unstemmed	Diffusion-limited association of disordered protein by non-native electrostatic interactions
title_sort	diffusion-limited association of disordered protein by non-native electrostatic interactions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/70516a3454314676950dba1a16adcf2d
work_keys_str_mv	AT jaeyeolkim diffusionlimitedassociationofdisorderedproteinbynonnativeelectrostaticinteractions AT fanjiemeng diffusionlimitedassociationofdisorderedproteinbynonnativeelectrostaticinteractions AT janghyunyoo diffusionlimitedassociationofdisorderedproteinbynonnativeelectrostaticinteractions AT hoisungchung diffusionlimitedassociationofdisorderedproteinbynonnativeelectrostaticinteractions
_version_	1718390597715230720

Diffusion-limited association of disordered protein by non-native electrostatic interactions

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