Pre-mitotic genome re-organisation bookends the B cell differentiation process

Pre-mitotic genome re-organisation bookends the B cell differentiation process

During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs p...

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Autores principales: Wing Fuk Chan, Hannah D. Coughlan, Jie H. S. Zhou, Christine R. Keenan, Naiara G. Bediaga, Philip D. Hodgkin, Gordon K. Smyth, Timothy M. Johanson, Rhys S. Allan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/7053b41411834244926ee8cb364e2b61
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spelling oai:doaj.org-article:7053b41411834244926ee8cb364e2b612021-12-02T13:33:02ZPre-mitotic genome re-organisation bookends the B cell differentiation process10.1038/s41467-021-21536-22041-1723https://doaj.org/article/7053b41411834244926ee8cb364e2b612021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21536-2https://doaj.org/toc/2041-1723During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.Wing Fuk ChanHannah D. CoughlanJie H. S. ZhouChristine R. KeenanNaiara G. BediagaPhilip D. HodgkinGordon K. SmythTimothy M. JohansonRhys S. AllanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wing Fuk Chan
Hannah D. Coughlan
Jie H. S. Zhou
Christine R. Keenan
Naiara G. Bediaga
Philip D. Hodgkin
Gordon K. Smyth
Timothy M. Johanson
Rhys S. Allan
Pre-mitotic genome re-organisation bookends the B cell differentiation process
description During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.
format article
author Wing Fuk Chan
Hannah D. Coughlan
Jie H. S. Zhou
Christine R. Keenan
Naiara G. Bediaga
Philip D. Hodgkin
Gordon K. Smyth
Timothy M. Johanson
Rhys S. Allan
author_facet Wing Fuk Chan
Hannah D. Coughlan
Jie H. S. Zhou
Christine R. Keenan
Naiara G. Bediaga
Philip D. Hodgkin
Gordon K. Smyth
Timothy M. Johanson
Rhys S. Allan
author_sort Wing Fuk Chan
title Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_short Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_full Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_fullStr Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_full_unstemmed Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_sort pre-mitotic genome re-organisation bookends the b cell differentiation process
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7053b41411834244926ee8cb364e2b61
work_keys_str_mv AT wingfukchan premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT hannahdcoughlan premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT jiehszhou premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT christinerkeenan premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT naiaragbediaga premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT philipdhodgkin premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT gordonksmyth premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT timothymjohanson premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
AT rhyssallan premitoticgenomereorganisationbookendsthebcelldifferentiationprocess
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