cGMP signaling pathway that modulates NF-κB activation in innate immune responses
Summary: The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate...
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Elsevier
2021
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oai:doaj.org-article:705469bd7383460088a2bdbb5aebbb712021-11-28T04:37:12ZcGMP signaling pathway that modulates NF-κB activation in innate immune responses2589-004210.1016/j.isci.2021.103473https://doaj.org/article/705469bd7383460088a2bdbb5aebbb712021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014449https://doaj.org/toc/2589-0042Summary: The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C. Gyc76C produces cyclic guanosine monophosphate (cGMP) and modulates NF-κB signaling through the downstream Tollreceptor components dMyd88, Pelle, Tube, and Dif/Dorsal (NF-κB). The cGMP signaling pathway comprises a membrane-localized cGMP-dependent protein kinase (cGK) called DG2 and protein phosphatase 2A (PP2A) and is crucial for host survival against Gram-positive bacterial infections in Drosophila. A membrane-bound cGK, PRKG2, also modulates NF-κB activation via PP2A in human cells, indicating that modulation of NF-κB activation in innate immunity by the cGMP signaling pathway is evolutionarily conserved.Hirotaka KanohShinzo IwashitaTakayuki KuraishiAkira GotoNaoyuki FuseHaruna UenoMariko NimuraTomohito OyamaChang TangRyo WatanabeAki HoriYoshiki MomiuchiHiroki IshikawaHiroaki SuzukiKumiko NabeTakeshi TakagakiMasataka FukuzakiLi-Li TongSinya YamadaYoshiteru OshimaToshiro AigakiJulian A.T. DowShireen-Anne DaviesShoichiro KurataElsevierarticleBiological sciencesImmune responseGenomicsScienceQENiScience, Vol 24, Iss 12, Pp 103473- (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Biological sciences Immune response Genomics Science Q |
| spellingShingle |
Biological sciences Immune response Genomics Science Q Hirotaka Kanoh Shinzo Iwashita Takayuki Kuraishi Akira Goto Naoyuki Fuse Haruna Ueno Mariko Nimura Tomohito Oyama Chang Tang Ryo Watanabe Aki Hori Yoshiki Momiuchi Hiroki Ishikawa Hiroaki Suzuki Kumiko Nabe Takeshi Takagaki Masataka Fukuzaki Li-Li Tong Sinya Yamada Yoshiteru Oshima Toshiro Aigaki Julian A.T. Dow Shireen-Anne Davies Shoichiro Kurata cGMP signaling pathway that modulates NF-κB activation in innate immune responses |
| description |
Summary: The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C. Gyc76C produces cyclic guanosine monophosphate (cGMP) and modulates NF-κB signaling through the downstream Tollreceptor components dMyd88, Pelle, Tube, and Dif/Dorsal (NF-κB). The cGMP signaling pathway comprises a membrane-localized cGMP-dependent protein kinase (cGK) called DG2 and protein phosphatase 2A (PP2A) and is crucial for host survival against Gram-positive bacterial infections in Drosophila. A membrane-bound cGK, PRKG2, also modulates NF-κB activation via PP2A in human cells, indicating that modulation of NF-κB activation in innate immunity by the cGMP signaling pathway is evolutionarily conserved. |
| format |
article |
| author |
Hirotaka Kanoh Shinzo Iwashita Takayuki Kuraishi Akira Goto Naoyuki Fuse Haruna Ueno Mariko Nimura Tomohito Oyama Chang Tang Ryo Watanabe Aki Hori Yoshiki Momiuchi Hiroki Ishikawa Hiroaki Suzuki Kumiko Nabe Takeshi Takagaki Masataka Fukuzaki Li-Li Tong Sinya Yamada Yoshiteru Oshima Toshiro Aigaki Julian A.T. Dow Shireen-Anne Davies Shoichiro Kurata |
| author_facet |
Hirotaka Kanoh Shinzo Iwashita Takayuki Kuraishi Akira Goto Naoyuki Fuse Haruna Ueno Mariko Nimura Tomohito Oyama Chang Tang Ryo Watanabe Aki Hori Yoshiki Momiuchi Hiroki Ishikawa Hiroaki Suzuki Kumiko Nabe Takeshi Takagaki Masataka Fukuzaki Li-Li Tong Sinya Yamada Yoshiteru Oshima Toshiro Aigaki Julian A.T. Dow Shireen-Anne Davies Shoichiro Kurata |
| author_sort |
Hirotaka Kanoh |
| title |
cGMP signaling pathway that modulates NF-κB activation in innate immune responses |
| title_short |
cGMP signaling pathway that modulates NF-κB activation in innate immune responses |
| title_full |
cGMP signaling pathway that modulates NF-κB activation in innate immune responses |
| title_fullStr |
cGMP signaling pathway that modulates NF-κB activation in innate immune responses |
| title_full_unstemmed |
cGMP signaling pathway that modulates NF-κB activation in innate immune responses |
| title_sort |
cgmp signaling pathway that modulates nf-κb activation in innate immune responses |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/705469bd7383460088a2bdbb5aebbb71 |
| work_keys_str_mv |
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