Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection

Introduction. Chikungunya virus infection (CKV) may lead to chronic arthritis in up to 40% of the patients. There are previous data regarding positive auto antibodies in CKV. Objective is to systematically evaluate the prevalence of auto antibodies in CKV patients. Methods. All study participants ha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	J. F. Carvalho, L. R. Cordeiro, F. F. Silva, L. Mota, C. Rodrigues, C. F. Andrade, C. Caldas
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	chikungunya autoantibodies autoimmunity arboviruses rheumatoid arthritis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/7055ad28cd674e15ad36daf534f23ba1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7055ad28cd674e15ad36daf534f23ba1
record_format	dspace
spelling	oai:doaj.org-article:7055ad28cd674e15ad36daf534f23ba12021-11-22T07:09:56ZProfile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection2220-76192313-739810.15789/2220-7619-POS-1614https://doaj.org/article/7055ad28cd674e15ad36daf534f23ba12021-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1614https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Introduction. Chikungunya virus infection (CKV) may lead to chronic arthritis in up to 40% of the patients. There are previous data regarding positive auto antibodies in CKV. Objective is to systematically evaluate the prevalence of auto antibodies in CKV patients. Methods. All study participants had clinical manifestations being CKV positive at least serologally or by RT-PCR data. The following autoantibodies were assessed: antinuclear antibodies (ANA), anti-dsDNA, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, anti-U1RNP, IgG and IgM anticardiolipin, anticyclic citrullinated peptide (antiCCP), rheumatoid factor (RF), antiribosomal P protein, lupus anticoagulant, anti-Jo-1 and anti-Scl-70. CH100, C3 and C4 complement components, serum levels of immunoglobulins, C-reactive protein, erythrocyte sedimentation rate, alpha1-acid glycoprotein, antithyroglobulin, antithyroperoxidase, TRAb, 25 hydroxyvitamin D (25OHD), dengue and zika IgG and IgM antibodies were also measured. Results. 30 CKV patients were included. Mean age was 59.1±15.7 years, 85% females and 77% Caucasian subjects. Disease duration comprised 4.9±4.0 months. Oligoarthritis was observed in 93% cases. Mean C-reactive protein levels were 10.1±6.8 ng/dL, erythrocyte sedimentation rate — 34.2±19.9 mm/1st hour and alpha1-acid glycoprotein 115.5±52.6 mg/dL. Intramuscular betamethasone depot single dose injection was administered in 54%, prednisone — in 15% and methotrexate — in 23% cases. Importantly, 1/30 (3.3%) cases was positive for ANA, 4/30 (13.3%) — for RF and none was positive for anti-CCP or any other autoantibodies. Complement and immunoglobulin levels were all within the normal range. Low levels of 25OHD were observed in 88% cases.J. F. CarvalhoL. R. CordeiroF. F. SilvaL. MotaC. RodriguesC. F. AndradeC. CaldasSankt-Peterburg : NIIÈM imeni Pasteraarticlechikungunyaautoantibodiesautoimmunityarbovirusesrheumatoid arthritisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 5, Pp 979-983 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	chikungunya autoantibodies autoimmunity arboviruses rheumatoid arthritis Infectious and parasitic diseases RC109-216
spellingShingle	chikungunya autoantibodies autoimmunity arboviruses rheumatoid arthritis Infectious and parasitic diseases RC109-216 J. F. Carvalho L. R. Cordeiro F. F. Silva L. Mota C. Rodrigues C. F. Andrade C. Caldas Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection
description	Introduction. Chikungunya virus infection (CKV) may lead to chronic arthritis in up to 40% of the patients. There are previous data regarding positive auto antibodies in CKV. Objective is to systematically evaluate the prevalence of auto antibodies in CKV patients. Methods. All study participants had clinical manifestations being CKV positive at least serologally or by RT-PCR data. The following autoantibodies were assessed: antinuclear antibodies (ANA), anti-dsDNA, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, anti-U1RNP, IgG and IgM anticardiolipin, anticyclic citrullinated peptide (antiCCP), rheumatoid factor (RF), antiribosomal P protein, lupus anticoagulant, anti-Jo-1 and anti-Scl-70. CH100, C3 and C4 complement components, serum levels of immunoglobulins, C-reactive protein, erythrocyte sedimentation rate, alpha1-acid glycoprotein, antithyroglobulin, antithyroperoxidase, TRAb, 25 hydroxyvitamin D (25OHD), dengue and zika IgG and IgM antibodies were also measured. Results. 30 CKV patients were included. Mean age was 59.1±15.7 years, 85% females and 77% Caucasian subjects. Disease duration comprised 4.9±4.0 months. Oligoarthritis was observed in 93% cases. Mean C-reactive protein levels were 10.1±6.8 ng/dL, erythrocyte sedimentation rate — 34.2±19.9 mm/1st hour and alpha1-acid glycoprotein 115.5±52.6 mg/dL. Intramuscular betamethasone depot single dose injection was administered in 54%, prednisone — in 15% and methotrexate — in 23% cases. Importantly, 1/30 (3.3%) cases was positive for ANA, 4/30 (13.3%) — for RF and none was positive for anti-CCP or any other autoantibodies. Complement and immunoglobulin levels were all within the normal range. Low levels of 25OHD were observed in 88% cases.
format	article
author	J. F. Carvalho L. R. Cordeiro F. F. Silva L. Mota C. Rodrigues C. F. Andrade C. Caldas
author_facet	J. F. Carvalho L. R. Cordeiro F. F. Silva L. Mota C. Rodrigues C. F. Andrade C. Caldas
author_sort	J. F. Carvalho
title	Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection
title_short	Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection
title_full	Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection
title_fullStr	Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection
title_full_unstemmed	Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection
title_sort	profile of several autoantibodies, complement and vitamin d levels in brazilian patients with chikungunya infection
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/7055ad28cd674e15ad36daf534f23ba1
work_keys_str_mv	AT jfcarvalho profileofseveralautoantibodiescomplementandvitamindlevelsinbrazilianpatientswithchikungunyainfection AT lrcordeiro profileofseveralautoantibodiescomplementandvitamindlevelsinbrazilianpatientswithchikungunyainfection AT ffsilva profileofseveralautoantibodiescomplementandvitamindlevelsinbrazilianpatientswithchikungunyainfection AT lmota profileofseveralautoantibodiescomplementandvitamindlevelsinbrazilianpatientswithchikungunyainfection AT crodrigues profileofseveralautoantibodiescomplementandvitamindlevelsinbrazilianpatientswithchikungunyainfection AT cfandrade profileofseveralautoantibodiescomplementandvitamindlevelsinbrazilianpatientswithchikungunyainfection AT ccaldas profileofseveralautoantibodiescomplementandvitamindlevelsinbrazilianpatientswithchikungunyainfection
_version_	1718417861850955776

Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection

Ejemplares similares