Intestinal non-canonical NFκB signaling shapes the local and systemic immune response
Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut in...
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Nature Portfolio
2019
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oai:doaj.org-article:7055cae8527e4457b716f2c0885ec9b12021-12-02T14:39:41ZIntestinal non-canonical NFκB signaling shapes the local and systemic immune response10.1038/s41467-019-08581-82041-1723https://doaj.org/article/7055cae8527e4457b716f2c0885ec9b12019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08581-8https://doaj.org/toc/2041-1723Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut inflammation and inflammatory bowel disease.Sadeesh K. RamakrishnanHuabing ZhangXiaoya MaInkyung JungAndrew J. SchwartzDaniel TrinerSamantha N. DevenportNupur K. DasXiang XueMelody Y. ZengYinling HuRichard M. MortensenJoel K GreensonMarilia CascalhoChristiane E. WobusJustin A. ColacinoGabriel NunezLiangyou RuiYatrik M. ShahNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sadeesh K. Ramakrishnan Huabing Zhang Xiaoya Ma Inkyung Jung Andrew J. Schwartz Daniel Triner Samantha N. Devenport Nupur K. Das Xiang Xue Melody Y. Zeng Yinling Hu Richard M. Mortensen Joel K Greenson Marilia Cascalho Christiane E. Wobus Justin A. Colacino Gabriel Nunez Liangyou Rui Yatrik M. Shah Intestinal non-canonical NFκB signaling shapes the local and systemic immune response |
| description |
Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut inflammation and inflammatory bowel disease. |
| format |
article |
| author |
Sadeesh K. Ramakrishnan Huabing Zhang Xiaoya Ma Inkyung Jung Andrew J. Schwartz Daniel Triner Samantha N. Devenport Nupur K. Das Xiang Xue Melody Y. Zeng Yinling Hu Richard M. Mortensen Joel K Greenson Marilia Cascalho Christiane E. Wobus Justin A. Colacino Gabriel Nunez Liangyou Rui Yatrik M. Shah |
| author_facet |
Sadeesh K. Ramakrishnan Huabing Zhang Xiaoya Ma Inkyung Jung Andrew J. Schwartz Daniel Triner Samantha N. Devenport Nupur K. Das Xiang Xue Melody Y. Zeng Yinling Hu Richard M. Mortensen Joel K Greenson Marilia Cascalho Christiane E. Wobus Justin A. Colacino Gabriel Nunez Liangyou Rui Yatrik M. Shah |
| author_sort |
Sadeesh K. Ramakrishnan |
| title |
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response |
| title_short |
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response |
| title_full |
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response |
| title_fullStr |
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response |
| title_full_unstemmed |
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response |
| title_sort |
intestinal non-canonical nfκb signaling shapes the local and systemic immune response |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7055cae8527e4457b716f2c0885ec9b1 |
| work_keys_str_mv |
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1718390536999534592 |