Intestinal non-canonical NFκB signaling shapes the local and systemic immune response

Intestinal non-canonical NFκB signaling shapes the local and systemic immune response

Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut in...

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Bibliographic Details
Main Authors: Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Xiang Xue, Melody Y. Zeng, Yinling Hu, Richard M. Mortensen, Joel K Greenson, Marilia Cascalho, Christiane E. Wobus, Justin A. Colacino, Gabriel Nunez, Liangyou Rui, Yatrik M. Shah
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/7055cae8527e4457b716f2c0885ec9b1
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https://doaj.org/article/7055cae8527e4457b716f2c0885ec9b1

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