A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma

A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma

Abstract Persistent or recurrent retinoblastoma (RB) is associated with the presence of vitreous or/and subretinal seeds in advanced RB and represents a major cause of therapeutic failure. This necessitates the development of novel therapies and thus requires a model of advanced RB for testing candi...

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Bibliographic Details
Main Authors: Duangporn Saengwimol, Duangnate Rojanaporn, Vijender Chaitankar, Pamorn Chittavanich, Rangsima Aroonroch, Tatpong Boontawon, Weerin Thammachote, Natini Jinawath, Suradej Hongeng, Rossukon Kaewkhaw
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Organoid Models
Retinal Tumors
Subretinal Seeds
Combined Drug Regimens
Topotecan
Medicine
R
Science
Q
Online Access:https://doaj.org/article/7055f181010d4848b2eaf2b999543e4e
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https://doaj.org/article/7055f181010d4848b2eaf2b999543e4e

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