Network-based in silico drug efficacy screening

Attempts to predict novel use for existing drugs rarely consider information on the impact on the genes perturbed in a given disease. Here, the authors present a novel network-based drug-disease proximity measure that provides insight on gene specific therapeutic effect of drugs and may facilitate d...

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Autores principales:	Emre Guney, Jörg Menche, Marc Vidal, Albert-László Barábasi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7056300b2e664a3daefdec33e6639c3e
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spelling	oai:doaj.org-article:7056300b2e664a3daefdec33e6639c3e2021-12-02T17:33:21ZNetwork-based in silico drug efficacy screening10.1038/ncomms103312041-1723https://doaj.org/article/7056300b2e664a3daefdec33e6639c3e2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10331https://doaj.org/toc/2041-1723Attempts to predict novel use for existing drugs rarely consider information on the impact on the genes perturbed in a given disease. Here, the authors present a novel network-based drug-disease proximity measure that provides insight on gene specific therapeutic effect of drugs and may facilitate drug repurposing.Emre GuneyJörg MencheMarc VidalAlbert-László BarábasiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emre Guney Jörg Menche Marc Vidal Albert-László Barábasi Network-based in silico drug efficacy screening
description	Attempts to predict novel use for existing drugs rarely consider information on the impact on the genes perturbed in a given disease. Here, the authors present a novel network-based drug-disease proximity measure that provides insight on gene specific therapeutic effect of drugs and may facilitate drug repurposing.
format	article
author	Emre Guney Jörg Menche Marc Vidal Albert-László Barábasi
author_facet	Emre Guney Jörg Menche Marc Vidal Albert-László Barábasi
author_sort	Emre Guney
title	Network-based in silico drug efficacy screening
title_short	Network-based in silico drug efficacy screening
title_full	Network-based in silico drug efficacy screening
title_fullStr	Network-based in silico drug efficacy screening
title_full_unstemmed	Network-based in silico drug efficacy screening
title_sort	network-based in silico drug efficacy screening
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7056300b2e664a3daefdec33e6639c3e
work_keys_str_mv	AT emreguney networkbasedinsilicodrugefficacyscreening AT jorgmenche networkbasedinsilicodrugefficacyscreening AT marcvidal networkbasedinsilicodrugefficacyscreening AT albertlaszlobarabasi networkbasedinsilicodrugefficacyscreening
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Network-based in silico drug efficacy screening

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