Network-based in silico drug efficacy screening

Attempts to predict novel use for existing drugs rarely consider information on the impact on the genes perturbed in a given disease. Here, the authors present a novel network-based drug-disease proximity measure that provides insight on gene specific therapeutic effect of drugs and may facilitate d...

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Auteurs principaux: Emre Guney, Jörg Menche, Marc Vidal, Albert-László Barábasi
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/7056300b2e664a3daefdec33e6639c3e
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