Critical evaluation of biodegradable polymers used in nanodrugs

Edgar Marin,1–3 Maria Isabel Briceño,2 Catherina Caballero-George11Unit of Pharmacology, Center of Biodiversity and Drug Discovery, Institute of Scientific Research and High Technology Services, 2Nano Dispersions Technology, Panama, Republic of Panama; 3Department of Biotechnolo...

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Autores principales:	Marin E, Brice&ntilde;o MI, Caballero-George C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/70591a40870f451d884e91f7c97ac497
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spelling	oai:doaj.org-article:70591a40870f451d884e91f7c97ac4972021-12-02T05:49:31ZCritical evaluation of biodegradable polymers used in nanodrugs1176-91141178-2013https://doaj.org/article/70591a40870f451d884e91f7c97ac4972013-08-01T00:00:00Zhttp://www.dovepress.com/critical-evaluation-of-biodegradable-polymers-used-in-nanodrugs-a14065https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Edgar Marin,1–3 Maria Isabel Briceño,2 Catherina Caballero-George11Unit of Pharmacology, Center of Biodiversity and Drug Discovery, Institute of Scientific Research and High Technology Services, 2Nano Dispersions Technology, Panama, Republic of Panama; 3Department of Biotechnology, Archaria Nagarjuna University, Guntur, IndiaAbstract: Use of biodegradable polymers for biomedical applications has increased in recent decades due to their biocompatibility, biodegradability, flexibility, and minimal side effects. Applications of these materials include creation of skin, blood vessels, cartilage scaffolds, and nanosystems for drug delivery. These biodegradable polymeric nanoparticles enhance properties such as bioavailability and stability, and provide controlled release of bioactive compounds. This review evaluates the classification, synthesis, degradation mechanisms, and biological applications of the biodegradable polymers currently being studied as drug delivery carriers. In addition, the use of nanosystems to solve current drug delivery problems are reviewed.Keywords: biodegradable polymers, nanoparticles, drug delivery, cellular uptake, biomedical applicationsMarin EBrice&ntilde;o MICaballero-George CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 3071-3091 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Marin E Brice&ntilde;o MI Caballero-George C Critical evaluation of biodegradable polymers used in nanodrugs
description	Edgar Marin,1–3 Maria Isabel Briceño,2 Catherina Caballero-George11Unit of Pharmacology, Center of Biodiversity and Drug Discovery, Institute of Scientific Research and High Technology Services, 2Nano Dispersions Technology, Panama, Republic of Panama; 3Department of Biotechnology, Archaria Nagarjuna University, Guntur, IndiaAbstract: Use of biodegradable polymers for biomedical applications has increased in recent decades due to their biocompatibility, biodegradability, flexibility, and minimal side effects. Applications of these materials include creation of skin, blood vessels, cartilage scaffolds, and nanosystems for drug delivery. These biodegradable polymeric nanoparticles enhance properties such as bioavailability and stability, and provide controlled release of bioactive compounds. This review evaluates the classification, synthesis, degradation mechanisms, and biological applications of the biodegradable polymers currently being studied as drug delivery carriers. In addition, the use of nanosystems to solve current drug delivery problems are reviewed.Keywords: biodegradable polymers, nanoparticles, drug delivery, cellular uptake, biomedical applications
format	article
author	Marin E Brice&ntilde;o MI Caballero-George C
author_facet	Marin E Brice&ntilde;o MI Caballero-George C
author_sort	Marin E
title	Critical evaluation of biodegradable polymers used in nanodrugs
title_short	Critical evaluation of biodegradable polymers used in nanodrugs
title_full	Critical evaluation of biodegradable polymers used in nanodrugs
title_fullStr	Critical evaluation of biodegradable polymers used in nanodrugs
title_full_unstemmed	Critical evaluation of biodegradable polymers used in nanodrugs
title_sort	critical evaluation of biodegradable polymers used in nanodrugs
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/70591a40870f451d884e91f7c97ac497
work_keys_str_mv	AT marine criticalevaluationofbiodegradablepolymersusedinnanodrugs AT briceampntildeomi criticalevaluationofbiodegradablepolymersusedinnanodrugs AT caballerogeorgec criticalevaluationofbiodegradablepolymersusedinnanodrugs
_version_	1718400235091263488

Critical evaluation of biodegradable polymers used in nanodrugs

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