Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study

Abstract Intracranial pressure (ICP) monitoring is important in managing neurosurgical, neurological, and ophthalmological patients with open-angle glaucoma. Non-invasive two-depth transcranial Doppler (TCD) technique is used in a novel method for ICP snapshot measurement that has been previously in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Paulius Lucinskas, Mantas Deimantavicius, Laimonas Bartusis, Rolandas Zakelis, Edgaras Misiulis, Algis Dziugys, Yasin Hamarat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/705d8fe3469445e8af17ae741c700ac3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:705d8fe3469445e8af17ae741c700ac3
record_format	dspace
spelling	oai:doaj.org-article:705d8fe3469445e8af17ae741c700ac32021-12-02T13:20:13ZHuman ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study10.1038/s41598-021-83777-x2045-2322https://doaj.org/article/705d8fe3469445e8af17ae741c700ac32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83777-xhttps://doaj.org/toc/2045-2322Abstract Intracranial pressure (ICP) monitoring is important in managing neurosurgical, neurological, and ophthalmological patients with open-angle glaucoma. Non-invasive two-depth transcranial Doppler (TCD) technique is used in a novel method for ICP snapshot measurement that has been previously investigated prospectively, and the results showed clinically acceptable accuracy and precision. The aim of this study was to investigate possibility of using the ophthalmic artery (OA) as a pressure sensor for continuous ICP monitoring. First, numerical modeling was done to investigate the possibility, and then a pilot clinical study was conducted to compare two-depth TCD-based non-invasive ICP monitoring data with readings from an invasive Codman ICP microsensor from patients with severe traumatic brain injury. The numerical modeling showed that the systematic error of non-invasive ICP monitoring was < 1.0 mmHg after eliminating the intraorbital and blood pressure gradient. In a clinical study, a total of 1928 paired data points were collected, and the extreme data points of measured differences between invasive and non-invasive ICP were − 3.94 and 4.68 mmHg (95% CI − 2.55 to 2.72). The total mean and SD were 0.086 ± 1.34 mmHg, and the correlation coefficient was 0.94. The results show that the OA can be used as a linear natural pressure sensor and that it could potentially be possible to monitor the ICP for up to 1 h without recalibration.Paulius LucinskasMantas DeimantaviciusLaimonas BartusisRolandas ZakelisEdgaras MisiulisAlgis DziugysYasin HamaratNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paulius Lucinskas Mantas Deimantavicius Laimonas Bartusis Rolandas Zakelis Edgaras Misiulis Algis Dziugys Yasin Hamarat Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study
description	Abstract Intracranial pressure (ICP) monitoring is important in managing neurosurgical, neurological, and ophthalmological patients with open-angle glaucoma. Non-invasive two-depth transcranial Doppler (TCD) technique is used in a novel method for ICP snapshot measurement that has been previously investigated prospectively, and the results showed clinically acceptable accuracy and precision. The aim of this study was to investigate possibility of using the ophthalmic artery (OA) as a pressure sensor for continuous ICP monitoring. First, numerical modeling was done to investigate the possibility, and then a pilot clinical study was conducted to compare two-depth TCD-based non-invasive ICP monitoring data with readings from an invasive Codman ICP microsensor from patients with severe traumatic brain injury. The numerical modeling showed that the systematic error of non-invasive ICP monitoring was < 1.0 mmHg after eliminating the intraorbital and blood pressure gradient. In a clinical study, a total of 1928 paired data points were collected, and the extreme data points of measured differences between invasive and non-invasive ICP were − 3.94 and 4.68 mmHg (95% CI − 2.55 to 2.72). The total mean and SD were 0.086 ± 1.34 mmHg, and the correlation coefficient was 0.94. The results show that the OA can be used as a linear natural pressure sensor and that it could potentially be possible to monitor the ICP for up to 1 h without recalibration.
format	article
author	Paulius Lucinskas Mantas Deimantavicius Laimonas Bartusis Rolandas Zakelis Edgaras Misiulis Algis Dziugys Yasin Hamarat
author_facet	Paulius Lucinskas Mantas Deimantavicius Laimonas Bartusis Rolandas Zakelis Edgaras Misiulis Algis Dziugys Yasin Hamarat
author_sort	Paulius Lucinskas
title	Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study
title_short	Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study
title_full	Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study
title_fullStr	Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study
title_full_unstemmed	Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study
title_sort	human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/705d8fe3469445e8af17ae741c700ac3
work_keys_str_mv	AT pauliuslucinskas humanophthalmicarteryasasensorfornoninvasiveintracranialpressuremonitoringnumericalmodelingandinvivopilotstudy AT mantasdeimantavicius humanophthalmicarteryasasensorfornoninvasiveintracranialpressuremonitoringnumericalmodelingandinvivopilotstudy AT laimonasbartusis humanophthalmicarteryasasensorfornoninvasiveintracranialpressuremonitoringnumericalmodelingandinvivopilotstudy AT rolandaszakelis humanophthalmicarteryasasensorfornoninvasiveintracranialpressuremonitoringnumericalmodelingandinvivopilotstudy AT edgarasmisiulis humanophthalmicarteryasasensorfornoninvasiveintracranialpressuremonitoringnumericalmodelingandinvivopilotstudy AT algisdziugys humanophthalmicarteryasasensorfornoninvasiveintracranialpressuremonitoringnumericalmodelingandinvivopilotstudy AT yasinhamarat humanophthalmicarteryasasensorfornoninvasiveintracranialpressuremonitoringnumericalmodelingandinvivopilotstudy
_version_	1718393217736507392

Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study

Ejemplares similares