Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1
Abstract Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells of the inner ear. A closely related homolog, TMC2, is expressed transiently in the neonatal mouse cochlea and can enable sensory transduc...
Guardado en:
Autores principales: | Yukako Asai, Bifeng Pan, Carl Nist-Lund, Alice Galvin, Andrei N. Lukashkin, Victoria A. Lukashkina, Tianwen Chen, Wu Zhou, Hong Zhu, Ian J. Russell, Jeffrey R. Holt, Gwenaelle S. G. Géléoc |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/7060bb4179c3426d8a8e22cd46477d42 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
por: Carl A. Nist-Lund, et al.
Publicado: (2019) -
Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
por: Carl A. Nist-Lund, et al.
Publicado: (2019) -
CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
por: Arnaud P. J. Giese, et al.
Publicado: (2017) -
HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear.
por: Geoffrey C Horwitz, et al.
Publicado: (2010) -
Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses
por: John Lee, et al.
Publicado: (2021)