RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.

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Detalles Bibliográficos
Autores principales: Barbara Nicol, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/70611c2bdf5d4776a09548dc9ccd8240
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Sumario:Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.

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