RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.

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Autores principales:	Barbara Nicol, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70611c2bdf5d4776a09548dc9ccd8240
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spelling	oai:doaj.org-article:70611c2bdf5d4776a09548dc9ccd82402021-12-02T17:32:09ZRUNX1 maintains the identity of the fetal ovary through an interplay with FOXL210.1038/s41467-019-13060-12041-1723https://doaj.org/article/70611c2bdf5d4776a09548dc9ccd82402019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13060-1https://doaj.org/toc/2041-1723Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.Barbara NicolSara A. GrimmFrédéric ChalmelEstelle LecluzeMaëlle PannetierEric PailhouxElodie Dupin-De-BeyssatYann GuiguenBlanche CapelHumphrey H.-C. YaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Barbara Nicol Sara A. Grimm Frédéric Chalmel Estelle Lecluze Maëlle Pannetier Eric Pailhoux Elodie Dupin-De-Beyssat Yann Guiguen Blanche Capel Humphrey H.-C. Yao RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
description	Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.
format	article
author	Barbara Nicol Sara A. Grimm Frédéric Chalmel Estelle Lecluze Maëlle Pannetier Eric Pailhoux Elodie Dupin-De-Beyssat Yann Guiguen Blanche Capel Humphrey H.-C. Yao
author_facet	Barbara Nicol Sara A. Grimm Frédéric Chalmel Estelle Lecluze Maëlle Pannetier Eric Pailhoux Elodie Dupin-De-Beyssat Yann Guiguen Blanche Capel Humphrey H.-C. Yao
author_sort	Barbara Nicol
title	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_short	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_full	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_fullStr	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_full_unstemmed	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_sort	runx1 maintains the identity of the fetal ovary through an interplay with foxl2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/70611c2bdf5d4776a09548dc9ccd8240
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RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

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