LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES

Response of human natural killer (NK) cell populations (NKP) against tumors in the presence of viruses was evaluated as a quite variable, early adapting for the pathological signals in organism, mobile and selective combination agents. NKP act as a result of co-functioning between the receptor lecti...

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Autores principales:	M. V. Lakhtin, V. M. Lakhtin, V. A. Aleshkin, S. S. Afanasiev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	cells nk cell populations receptor lectins glycoconjugates cytokines innate immunity mucosal immunity dysbioses probiotic lectins antitumor strategies antiviral strategies Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/706158c88b7d4f8b99af5f33f12ce285
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spelling	oai:doaj.org-article:706158c88b7d4f8b99af5f33f12ce2852021-11-18T08:03:48ZLECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES1563-06252313-741X10.15789/1563-0625-2019-4-595-602https://doaj.org/article/706158c88b7d4f8b99af5f33f12ce2852019-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1620https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XResponse of human natural killer (NK) cell populations (NKP) against tumors in the presence of viruses was evaluated as a quite variable, early adapting for the pathological signals in organism, mobile and selective combination agents. NKP act as a result of co-functioning between the receptor lectins (RL) recognizing glycopatterns (RL as triggers, initiators and basic agents for coupled activities), and Ig-like, cytotoxic and other additional communicative and effector receptors (superstructural, tuning for achievement of final effector-type NKP constructions required), and their ligands (modulators of final cell surface receptor mosaics). Such NKP created play important role in redistribution of NKP-induced antitumor/ antiviral cytokines in organism. Intercellular communicative potential of NKP also involves other innate and innate-like cells. Such extended communications of NKP provide a prospective and universal resource of human protection. NKP must be under consideration upon development of new maneuvre and relilable prophylactic and immunotherapeutic antitumor/ antiviral systems and vaccine strategies. The ways for the fine tuning (RL—KIR/ NCR/ CD/ their combinations) algorithms of RL-based creation of antitumor/ antiviral NKP are revealed. Key role is given to screening spectrum of patient NKP for development of communicative anticancer/ antiviral strategies. The status of NK compartment will characterize resistance of individuum/ contingent of individuums to viral infections of epidemiological significance, will play important role in anti-epidemic protection of regional population.M. V. LakhtinV. M. LakhtinV. A. AleshkinS. S. AfanasievSPb RAACIarticlecellsnk cell populationsreceptor lectinsglycoconjugatescytokinesinnate immunitymucosal immunitydysbiosesprobiotic lectinsantitumor strategiesantiviral strategiesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 4, Pp 595-602 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	cells nk cell populations receptor lectins glycoconjugates cytokines innate immunity mucosal immunity dysbioses probiotic lectins antitumor strategies antiviral strategies Immunologic diseases. Allergy RC581-607
spellingShingle	cells nk cell populations receptor lectins glycoconjugates cytokines innate immunity mucosal immunity dysbioses probiotic lectins antitumor strategies antiviral strategies Immunologic diseases. Allergy RC581-607 M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin S. S. Afanasiev LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES
description	Response of human natural killer (NK) cell populations (NKP) against tumors in the presence of viruses was evaluated as a quite variable, early adapting for the pathological signals in organism, mobile and selective combination agents. NKP act as a result of co-functioning between the receptor lectins (RL) recognizing glycopatterns (RL as triggers, initiators and basic agents for coupled activities), and Ig-like, cytotoxic and other additional communicative and effector receptors (superstructural, tuning for achievement of final effector-type NKP constructions required), and their ligands (modulators of final cell surface receptor mosaics). Such NKP created play important role in redistribution of NKP-induced antitumor/ antiviral cytokines in organism. Intercellular communicative potential of NKP also involves other innate and innate-like cells. Such extended communications of NKP provide a prospective and universal resource of human protection. NKP must be under consideration upon development of new maneuvre and relilable prophylactic and immunotherapeutic antitumor/ antiviral systems and vaccine strategies. The ways for the fine tuning (RL—KIR/ NCR/ CD/ their combinations) algorithms of RL-based creation of antitumor/ antiviral NKP are revealed. Key role is given to screening spectrum of patient NKP for development of communicative anticancer/ antiviral strategies. The status of NK compartment will characterize resistance of individuum/ contingent of individuums to viral infections of epidemiological significance, will play important role in anti-epidemic protection of regional population.
format	article
author	M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin S. S. Afanasiev
author_facet	M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin S. S. Afanasiev
author_sort	M. V. Lakhtin
title	LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES
title_short	LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES
title_full	LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES
title_fullStr	LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES
title_full_unstemmed	LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES
title_sort	lectin-dependent diversity of natural killer populations and communications against tumors and viruses
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/706158c88b7d4f8b99af5f33f12ce285
work_keys_str_mv	AT mvlakhtin lectindependentdiversityofnaturalkillerpopulationsandcommunicationsagainsttumorsandviruses AT vmlakhtin lectindependentdiversityofnaturalkillerpopulationsandcommunicationsagainsttumorsandviruses AT vaaleshkin lectindependentdiversityofnaturalkillerpopulationsandcommunicationsagainsttumorsandviruses AT ssafanasiev lectindependentdiversityofnaturalkillerpopulationsandcommunicationsagainsttumorsandviruses
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LECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSES

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