An MPER antibody neutralizes HIV-1 using germline features shared among donors

Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis shows how the antibody binds the MPER and Env on th...

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Autores principales:	Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, Michael B. Zwick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/706277bc9dfa4fb4814343163603b088
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spelling	oai:doaj.org-article:706277bc9dfa4fb4814343163603b0882021-12-02T17:01:47ZAn MPER antibody neutralizes HIV-1 using germline features shared among donors10.1038/s41467-019-12973-12041-1723https://doaj.org/article/706277bc9dfa4fb4814343163603b0882019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12973-1https://doaj.org/toc/2041-1723Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis shows how the antibody binds the MPER and Env on the viral membrane.Lei ZhangAdriana IrimiaLingling HeElise LandaisKimmo RantalainenDaniel P. LeamanThomas VollbrechtArmando StanoDaniel I. SandsArthur S. KimIAVI Protocol G InvestigatorsPascal PoignardDennis R. BurtonBen MurrellAndrew B. WardJiang ZhuIan A. WilsonMichael B. ZwickNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Zhang Adriana Irimia Lingling He Elise Landais Kimmo Rantalainen Daniel P. Leaman Thomas Vollbrecht Armando Stano Daniel I. Sands Arthur S. Kim IAVI Protocol G Investigators Pascal Poignard Dennis R. Burton Ben Murrell Andrew B. Ward Jiang Zhu Ian A. Wilson Michael B. Zwick An MPER antibody neutralizes HIV-1 using germline features shared among donors
description	Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis shows how the antibody binds the MPER and Env on the viral membrane.
format	article
author	Lei Zhang Adriana Irimia Lingling He Elise Landais Kimmo Rantalainen Daniel P. Leaman Thomas Vollbrecht Armando Stano Daniel I. Sands Arthur S. Kim IAVI Protocol G Investigators Pascal Poignard Dennis R. Burton Ben Murrell Andrew B. Ward Jiang Zhu Ian A. Wilson Michael B. Zwick
author_facet	Lei Zhang Adriana Irimia Lingling He Elise Landais Kimmo Rantalainen Daniel P. Leaman Thomas Vollbrecht Armando Stano Daniel I. Sands Arthur S. Kim IAVI Protocol G Investigators Pascal Poignard Dennis R. Burton Ben Murrell Andrew B. Ward Jiang Zhu Ian A. Wilson Michael B. Zwick
author_sort	Lei Zhang
title	An MPER antibody neutralizes HIV-1 using germline features shared among donors
title_short	An MPER antibody neutralizes HIV-1 using germline features shared among donors
title_full	An MPER antibody neutralizes HIV-1 using germline features shared among donors
title_fullStr	An MPER antibody neutralizes HIV-1 using germline features shared among donors
title_full_unstemmed	An MPER antibody neutralizes HIV-1 using germline features shared among donors
title_sort	mper antibody neutralizes hiv-1 using germline features shared among donors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/706277bc9dfa4fb4814343163603b088
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An MPER antibody neutralizes HIV-1 using germline features shared among donors

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