An MPER antibody neutralizes HIV-1 using germline features shared among donors
Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis shows how the antibody binds the MPER and Env on th...
Guardado en:
Autores principales: | Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, Michael B. Zwick |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/706277bc9dfa4fb4814343163603b088 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions
por: Pablo Carravilla, et al.
Publicado: (2019) -
Retention of paternal DNA methylome in the developing zebrafish germline
por: Ksenia Skvortsova, et al.
Publicado: (2019) -
Author Correction: A Donor Quality Index for liver transplantation: development, internal and external validation
por: Audrey Winter, et al.
Publicado: (2018) -
Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicity.
por: Nerea Huarte, et al.
Publicado: (2012) -
Interspecific germline transmission of cultured primordial germ cells.
por: Marie-Cecile van de Lavoir, et al.
Publicado: (2012)