DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine

DNA methylation is a work of adding a methyl group to the 5th carbon atom of cytosine in DNA sequence under the catalysis of DNA methyltransferase (DNMT) to produce 5-methyl cytosine. Some current studies have elucidated the mechanism of lung cancer occurrence and causes of lung cancer progression a...

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Autores principales:	Runzhang Liang, Xiaosong Li, Weiquan Li, Xiao Zhu, Chen Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	DNA methylation Lung cancer Liquid biopsy Biomarker Treatment Prognosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/706401cd5d384133bf96364bbf20a371
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spelling	oai:doaj.org-article:706401cd5d384133bf96364bbf20a3712021-11-16T04:36:10ZDNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine0753-332210.1016/j.biopha.2021.112202https://doaj.org/article/706401cd5d384133bf96364bbf20a3712021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221009860https://doaj.org/toc/0753-3322DNA methylation is a work of adding a methyl group to the 5th carbon atom of cytosine in DNA sequence under the catalysis of DNA methyltransferase (DNMT) to produce 5-methyl cytosine. Some current studies have elucidated the mechanism of lung cancer occurrence and causes of lung cancer progression and metastasis from the perspective of DNA methylation. Moreover, many studies have shown that smoking can change the methylation status of some gene loci, leading to the occurrence of lung cancer, especially central lung cancer. This review mainly introduces the role of DNA methylation in the pathogenesis, early diagnosis and screening, progression and metastasis, treatment, and prognosis of lung cancer, as well as the latest progress. We point out that methylation markers, sample tests, and methylation detection limit the clinical application of DNA methylation. If the liquid biopsy is to become the main force in lung cancer diagnosis, it must make efficient use of limited samples and improve the sensitivity and specificity of the tests. In addition, we also put forward our views on the future development direction of DNA methylation.Runzhang LiangXiaosong LiWeiquan LiXiao ZhuChen LiElsevierarticleDNA methylationLung cancerLiquid biopsyBiomarkerTreatmentPrognosisTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112202- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA methylation Lung cancer Liquid biopsy Biomarker Treatment Prognosis Therapeutics. Pharmacology RM1-950
spellingShingle	DNA methylation Lung cancer Liquid biopsy Biomarker Treatment Prognosis Therapeutics. Pharmacology RM1-950 Runzhang Liang Xiaosong Li Weiquan Li Xiao Zhu Chen Li DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine
description	DNA methylation is a work of adding a methyl group to the 5th carbon atom of cytosine in DNA sequence under the catalysis of DNA methyltransferase (DNMT) to produce 5-methyl cytosine. Some current studies have elucidated the mechanism of lung cancer occurrence and causes of lung cancer progression and metastasis from the perspective of DNA methylation. Moreover, many studies have shown that smoking can change the methylation status of some gene loci, leading to the occurrence of lung cancer, especially central lung cancer. This review mainly introduces the role of DNA methylation in the pathogenesis, early diagnosis and screening, progression and metastasis, treatment, and prognosis of lung cancer, as well as the latest progress. We point out that methylation markers, sample tests, and methylation detection limit the clinical application of DNA methylation. If the liquid biopsy is to become the main force in lung cancer diagnosis, it must make efficient use of limited samples and improve the sensitivity and specificity of the tests. In addition, we also put forward our views on the future development direction of DNA methylation.
format	article
author	Runzhang Liang Xiaosong Li Weiquan Li Xiao Zhu Chen Li
author_facet	Runzhang Liang Xiaosong Li Weiquan Li Xiao Zhu Chen Li
author_sort	Runzhang Liang
title	DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine
title_short	DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine
title_full	DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine
title_fullStr	DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine
title_full_unstemmed	DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine
title_sort	dna methylation in lung cancer patients: opening a 'window of life' under precision medicine
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/706401cd5d384133bf96364bbf20a371
work_keys_str_mv	AT runzhangliang dnamethylationinlungcancerpatientsopeningawindowoflifeunderprecisionmedicine AT xiaosongli dnamethylationinlungcancerpatientsopeningawindowoflifeunderprecisionmedicine AT weiquanli dnamethylationinlungcancerpatientsopeningawindowoflifeunderprecisionmedicine AT xiaozhu dnamethylationinlungcancerpatientsopeningawindowoflifeunderprecisionmedicine AT chenli dnamethylationinlungcancerpatientsopeningawindowoflifeunderprecisionmedicine
_version_	1718426730400579584

DNA methylation in lung cancer patients: Opening a 'window of life' under precision medicine

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