When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus

Maintaining glycemic control through intensive clinical management of patients with type 2 diabetes mellitus (T2DM) is well recognized to reduce the risk of diabetes-associated complications. Patients in Russia have high rates of microvascular and macrovascular complications as a result of undiagnos...

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Autores principales:	Elena V. Buryukova, Abdul Jabbar, Svetlana V. Elizarova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	diabetes mellitus, type 2 insulin insulin mixtures insulin intensification hemoglobin a glycosylated efficacy safety Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/7064630c00a648cdb4fccd13437a7832
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spelling	oai:doaj.org-article:7064630c00a648cdb4fccd13437a78322021-11-14T09:00:21ZWhen basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus2072-03512072-037810.14341/DM8824https://doaj.org/article/7064630c00a648cdb4fccd13437a78322017-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8824https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Maintaining glycemic control through intensive clinical management of patients with type 2 diabetes mellitus (T2DM) is well recognized to reduce the risk of diabetes-associated complications. Patients in Russia have high rates of microvascular and macrovascular complications as a result of undiagnosed, untreated, or inadequately treated diabetes, emphasizing the need for better clinical management. The introduction of basal insulin therapy is often necessary for patients with T2DM when oral antihyperglycemic drugs and lifestyle management strategies are no longer effective inmaintaining glycemic targets. However, after initiation of insulin, patients often remain on basal insulin for long periods despite suboptimal glycemic control, and intensification of insulin therapy is frequently necessary. Here, we report on several different insulin intensification strategies available to clinicians and their patients to improve glycemic control and the advantages and disadvantages of each approach. These strategies include the use of short- and long-acting insulins administered either as bolus doses or as premixed insulins. When selecting the most appropriate intensification strategy, clinicians should consider the lifestyle and treatment goals of their patients to help ensure treatment success.Elena V. BuryukovaAbdul JabbarSvetlana V. ElizarovaEndocrinology Research Centrearticlediabetes mellitus, type 2insulininsulin mixturesinsulin intensificationhemoglobin aglycosylatedefficacysafetyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 5, Pp 363-373 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus, type 2 insulin insulin mixtures insulin intensification hemoglobin a glycosylated efficacy safety Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus, type 2 insulin insulin mixtures insulin intensification hemoglobin a glycosylated efficacy safety Nutritional diseases. Deficiency diseases RC620-627 Elena V. Buryukova Abdul Jabbar Svetlana V. Elizarova When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
description	Maintaining glycemic control through intensive clinical management of patients with type 2 diabetes mellitus (T2DM) is well recognized to reduce the risk of diabetes-associated complications. Patients in Russia have high rates of microvascular and macrovascular complications as a result of undiagnosed, untreated, or inadequately treated diabetes, emphasizing the need for better clinical management. The introduction of basal insulin therapy is often necessary for patients with T2DM when oral antihyperglycemic drugs and lifestyle management strategies are no longer effective inmaintaining glycemic targets. However, after initiation of insulin, patients often remain on basal insulin for long periods despite suboptimal glycemic control, and intensification of insulin therapy is frequently necessary. Here, we report on several different insulin intensification strategies available to clinicians and their patients to improve glycemic control and the advantages and disadvantages of each approach. These strategies include the use of short- and long-acting insulins administered either as bolus doses or as premixed insulins. When selecting the most appropriate intensification strategy, clinicians should consider the lifestyle and treatment goals of their patients to help ensure treatment success.
format	article
author	Elena V. Buryukova Abdul Jabbar Svetlana V. Elizarova
author_facet	Elena V. Buryukova Abdul Jabbar Svetlana V. Elizarova
author_sort	Elena V. Buryukova
title	When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
title_short	When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
title_full	When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
title_fullStr	When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
title_full_unstemmed	When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
title_sort	when basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/7064630c00a648cdb4fccd13437a7832
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When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus

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