Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study

Peppermint leaf, sage leaf, thyme herb, and their preparations are common components of herbal medicinal products (HMPs). According to the European Pharmacopoeia guidelines, the above-mentioned plant substances are standardized for the content of essential oils, omitting polyphenols, which also have...

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Autores principales:	Agnieszka Bodalska, Adam Kowalczyk, Izabela Fecka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	herbal medicinal product stability rosmarinic acid (CAS No: 20283-92-5) luteolin-7-<i>O</i>-β-glucuronide (CAS No: 29741-10-4) luteolin-7-<i>O</i>-β-glucuronoside eriocitrin (CAS No: 13463-28-0) eriodictyol-7-<i>O</i>-rutinoside Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/7065014e5940469baf674df0e5ab9bd9
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spelling	oai:doaj.org-article:7065014e5940469baf674df0e5ab9bd92021-11-25T18:39:39ZStability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study10.3390/ph141111391424-8247https://doaj.org/article/7065014e5940469baf674df0e5ab9bd92021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1139https://doaj.org/toc/1424-8247Peppermint leaf, sage leaf, thyme herb, and their preparations are common components of herbal medicinal products (HMPs). According to the European Pharmacopoeia guidelines, the above-mentioned plant substances are standardized for the content of essential oils, omitting polyphenols, which also have a significant impact on their activities. The aim of this study was to evaluate the stability of the predominant polyphenols—rosmarinic acid, luteolin-7-<i>O</i>-β-glucuronide, and eriocitrin—in selected commercial liquid HMPs containing thyme, sage, and peppermint under long-term, intermediate, and accelerated testing conditions. Qualitative and quantitative analyses of these polyphenols were performed by the previously optimized and validated HPLC-DAD method. Rosmarinic acid stability was better in hydroethanolic than in an aqueous solution. The effect of the solvent on the stability of luteolin-7-<i>O</i>-β-glucuronide and eriocitrin could not be determined and requires further investigation. The present study is the first to analyze the stability of these compounds in commercial herbal medicinal products. The expiration dates proposed by the manufacturers of the tested HMPs did not guarantee stable levels of all analyzed polyphenols throughout the stated period. However, this study is preliminary and requires continuation on a larger number of medicinal products.Agnieszka BodalskaAdam KowalczykIzabela FeckaMDPI AGarticleherbal medicinal product stabilityrosmarinic acid (CAS No: 20283-92-5)luteolin-7-<i>O</i>-β-glucuronide (CAS No: 29741-10-4)luteolin-7-<i>O</i>-β-glucuronosideeriocitrin (CAS No: 13463-28-0)eriodictyol-7-<i>O</i>-rutinosideMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1139, p 1139 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	herbal medicinal product stability rosmarinic acid (CAS No: 20283-92-5) luteolin-7-<i>O</i>-β-glucuronide (CAS No: 29741-10-4) luteolin-7-<i>O</i>-β-glucuronoside eriocitrin (CAS No: 13463-28-0) eriodictyol-7-<i>O</i>-rutinoside Medicine R Pharmacy and materia medica RS1-441
spellingShingle	herbal medicinal product stability rosmarinic acid (CAS No: 20283-92-5) luteolin-7-<i>O</i>-β-glucuronide (CAS No: 29741-10-4) luteolin-7-<i>O</i>-β-glucuronoside eriocitrin (CAS No: 13463-28-0) eriodictyol-7-<i>O</i>-rutinoside Medicine R Pharmacy and materia medica RS1-441 Agnieszka Bodalska Adam Kowalczyk Izabela Fecka Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study
description	Peppermint leaf, sage leaf, thyme herb, and their preparations are common components of herbal medicinal products (HMPs). According to the European Pharmacopoeia guidelines, the above-mentioned plant substances are standardized for the content of essential oils, omitting polyphenols, which also have a significant impact on their activities. The aim of this study was to evaluate the stability of the predominant polyphenols—rosmarinic acid, luteolin-7-<i>O</i>-β-glucuronide, and eriocitrin—in selected commercial liquid HMPs containing thyme, sage, and peppermint under long-term, intermediate, and accelerated testing conditions. Qualitative and quantitative analyses of these polyphenols were performed by the previously optimized and validated HPLC-DAD method. Rosmarinic acid stability was better in hydroethanolic than in an aqueous solution. The effect of the solvent on the stability of luteolin-7-<i>O</i>-β-glucuronide and eriocitrin could not be determined and requires further investigation. The present study is the first to analyze the stability of these compounds in commercial herbal medicinal products. The expiration dates proposed by the manufacturers of the tested HMPs did not guarantee stable levels of all analyzed polyphenols throughout the stated period. However, this study is preliminary and requires continuation on a larger number of medicinal products.
format	article
author	Agnieszka Bodalska Adam Kowalczyk Izabela Fecka
author_facet	Agnieszka Bodalska Adam Kowalczyk Izabela Fecka
author_sort	Agnieszka Bodalska
title	Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study
title_short	Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study
title_full	Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study
title_fullStr	Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study
title_full_unstemmed	Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study
title_sort	stability of rosmarinic acid and flavonoid glycosides in liquid forms of herbal medicinal products—a preliminary study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7065014e5940469baf674df0e5ab9bd9
work_keys_str_mv	AT agnieszkabodalska stabilityofrosmarinicacidandflavonoidglycosidesinliquidformsofherbalmedicinalproductsapreliminarystudy AT adamkowalczyk stabilityofrosmarinicacidandflavonoidglycosidesinliquidformsofherbalmedicinalproductsapreliminarystudy AT izabelafecka stabilityofrosmarinicacidandflavonoidglycosidesinliquidformsofherbalmedicinalproductsapreliminarystudy
_version_	1718410841978568704

Stability of Rosmarinic Acid and Flavonoid Glycosides in Liquid Forms of Herbal Medicinal Products—A Preliminary Study

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