Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus

Introduction Endocan and endoglin have been shown to play a role in angiogenesis. Aberrant excessive angiogenesis is a main factor in the development of diabetic nephropathy. In this study we evaluated endocan and endoglin levels in diabetes patients with and without albuminuria and compared them wi...

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Autores principales:	Betül Ekiz-Bilir, Bülent Bilir, Murat Aydın, Neslihan Soysal-Atile
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	angiogenesis diabetic nephropathy endocan endoglin Medicine R
Acceso en línea:	https://doaj.org/article/706573eb33ca4374bf59f1511609330d
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spelling	oai:doaj.org-article:706573eb33ca4374bf59f1511609330d2021-12-02T19:15:49ZEvaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus1734-19221896-915110.5114/aoms.2018.79488https://doaj.org/article/706573eb33ca4374bf59f1511609330d2018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Evaluation-of-endocan-and-endoglin-levels-in-chronic-kidney-disease-due-to-diabetes,66880,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Endocan and endoglin have been shown to play a role in angiogenesis. Aberrant excessive angiogenesis is a main factor in the development of diabetic nephropathy. In this study we evaluated endocan and endoglin levels in diabetes patients with and without albuminuria and compared them with healthy subjects. Therefore we aimed at gaining a better understanding of the role of angiogenesis in diabetic nephropathy and to assess the predictive role of endocan and endoglin as markers of diabetic nephropathy progression. Material and methods Ninety-six type 2 diabetes patients were classified according to their 24-hour urinary albumin excretion rate. Forty type 2 diabetes patients with normoalbuminuria (urinary albumin excretion < 30 mg/day), 56 type 2 diabetes patients with diabetic nephropathy (with a urinary albumin excretion ≥ 30 mg/day) and 35 healthy non-diabetic control subjects were included. Their anthropometric features, arterial blood pressures, fasting glucose, glycated hemoglobin, urea, creatinine, lipids, endocan and endoglin levels were measured and compared to each other. Results Endocan and endoglin levels of diabetics patients were higher than those of the controls. In comparison of endocan and endoglin levels of diabetic nephropathy patients with controls, p-values were < 0.001 and 0.002 respectively. In comparison of normoalbuminuric diabetic patients with controls, p-values were 0.001 and 0.017 respectively. Endocan levels of diabetic nephropathy cases were higher than those of normoalbuminuric patients (p = 0.011) but there was no statistically significant difference in endoglin levels between them (p = 0.822). Conclusions Endocan might be a more reliable marker of diabetic nephropathy development than endoglin.Betül Ekiz-BilirBülent BilirMurat AydınNeslihan Soysal-AtileTermedia Publishing Housearticleangiogenesisdiabetic nephropathyendocanendoglinMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 86-91 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiogenesis diabetic nephropathy endocan endoglin Medicine R
spellingShingle	angiogenesis diabetic nephropathy endocan endoglin Medicine R Betül Ekiz-Bilir Bülent Bilir Murat Aydın Neslihan Soysal-Atile Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus
description	Introduction Endocan and endoglin have been shown to play a role in angiogenesis. Aberrant excessive angiogenesis is a main factor in the development of diabetic nephropathy. In this study we evaluated endocan and endoglin levels in diabetes patients with and without albuminuria and compared them with healthy subjects. Therefore we aimed at gaining a better understanding of the role of angiogenesis in diabetic nephropathy and to assess the predictive role of endocan and endoglin as markers of diabetic nephropathy progression. Material and methods Ninety-six type 2 diabetes patients were classified according to their 24-hour urinary albumin excretion rate. Forty type 2 diabetes patients with normoalbuminuria (urinary albumin excretion < 30 mg/day), 56 type 2 diabetes patients with diabetic nephropathy (with a urinary albumin excretion ≥ 30 mg/day) and 35 healthy non-diabetic control subjects were included. Their anthropometric features, arterial blood pressures, fasting glucose, glycated hemoglobin, urea, creatinine, lipids, endocan and endoglin levels were measured and compared to each other. Results Endocan and endoglin levels of diabetics patients were higher than those of the controls. In comparison of endocan and endoglin levels of diabetic nephropathy patients with controls, p-values were < 0.001 and 0.002 respectively. In comparison of normoalbuminuric diabetic patients with controls, p-values were 0.001 and 0.017 respectively. Endocan levels of diabetic nephropathy cases were higher than those of normoalbuminuric patients (p = 0.011) but there was no statistically significant difference in endoglin levels between them (p = 0.822). Conclusions Endocan might be a more reliable marker of diabetic nephropathy development than endoglin.
format	article
author	Betül Ekiz-Bilir Bülent Bilir Murat Aydın Neslihan Soysal-Atile
author_facet	Betül Ekiz-Bilir Bülent Bilir Murat Aydın Neslihan Soysal-Atile
author_sort	Betül Ekiz-Bilir
title	Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus
title_short	Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus
title_full	Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus
title_fullStr	Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus
title_full_unstemmed	Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus
title_sort	evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/706573eb33ca4374bf59f1511609330d
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Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus

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