Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor

Orally absorbable gold nanoparticles (AuNP) having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme (GBM) for patients with its highest incidence rate. Here, we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through th...

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Autores principales:	Hyung Shik Kim, Seung Jae Lee, Dong Yun Lee
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7066576e85c742809222a367a0751653
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spelling	oai:doaj.org-article:7066576e85c742809222a367a07516532021-11-04T04:35:54ZMilk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor2452-199X10.1016/j.bioactmat.2021.06.026https://doaj.org/article/7066576e85c742809222a367a07516532022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003121https://doaj.org/toc/2452-199XOrally absorbable gold nanoparticles (AuNP) having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme (GBM) for patients with its highest incidence rate. Here, we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin (Lf) and lactoferrin receptor (LfR) that is highly expressed in the intestine, blood-brain barrier and GBM. For stability and long circulation of AuNP, glutathione and polyethylene glycol (PEG) is introduced, which is called to Lf-PEG-AuNP. When Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice, 11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain, respectively, compared with unconjugated-AuNP. Therefore, orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor volume. Collectively, we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption, and that its efficient photothermal therapy is possible.Hyung Shik KimSeung Jae LeeDong Yun LeeKeAi Communications Co., Ltd.articleMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 35-48 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Hyung Shik Kim Seung Jae Lee Dong Yun Lee Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor
description	Orally absorbable gold nanoparticles (AuNP) having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme (GBM) for patients with its highest incidence rate. Here, we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin (Lf) and lactoferrin receptor (LfR) that is highly expressed in the intestine, blood-brain barrier and GBM. For stability and long circulation of AuNP, glutathione and polyethylene glycol (PEG) is introduced, which is called to Lf-PEG-AuNP. When Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice, 11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain, respectively, compared with unconjugated-AuNP. Therefore, orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor volume. Collectively, we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption, and that its efficient photothermal therapy is possible.
format	article
author	Hyung Shik Kim Seung Jae Lee Dong Yun Lee
author_facet	Hyung Shik Kim Seung Jae Lee Dong Yun Lee
author_sort	Hyung Shik Kim
title	Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor
title_short	Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor
title_full	Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor
title_fullStr	Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor
title_full_unstemmed	Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor
title_sort	milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/7066576e85c742809222a367a0751653
work_keys_str_mv	AT hyungshikkim milkproteinshelledgoldnanoparticleswithgastrointestinallyactiveabsorptionforaurotherapytobraintumor AT seungjaelee milkproteinshelledgoldnanoparticleswithgastrointestinallyactiveabsorptionforaurotherapytobraintumor AT dongyunlee milkproteinshelledgoldnanoparticleswithgastrointestinallyactiveabsorptionforaurotherapytobraintumor
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Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor

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