Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies

Abstract Butterfly glioblastoma (bGBM) is a rare brain tumor that invades both hemispheres by crossing the corpus callosum. bGBM is associated with a dismal prognosis with a median survival time of a few months. Surgical resection is a rare treatment option due to the unfavorable location and assume...

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Autores principales:	Rafał Chojak, Marta Koźba-Gosztyła, Katarzyna Słychan, Daniel Gajos, Marek Kotas, Michał Tyliszczak, Bogdan Czapiga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7066e9dfaba548318981b962e59df58b
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spelling	oai:doaj.org-article:7066e9dfaba548318981b962e59df58b2021-12-02T15:22:56ZImpact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies10.1038/s41598-021-93441-z2045-2322https://doaj.org/article/7066e9dfaba548318981b962e59df58b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93441-zhttps://doaj.org/toc/2045-2322Abstract Butterfly glioblastoma (bGBM) is a rare brain tumor that invades both hemispheres by crossing the corpus callosum. bGBM is associated with a dismal prognosis with a median survival time of a few months. Surgical resection is a rare treatment option due to the unfavorable location and assumed poor risk-to-benefit ratio. Therefore, a biopsy-alone approach is considered the main treatment option. This meta-analysis aimed to systematically evaluate whether resection of bGBM is associated with improved overall survival compared with biopsy alone. We searched three databases to find studies that compare resection with biopsy in 6-, 12- and 18-months overall survival in patients with bGBM. We calculated the pooled relative risk (RR) of mortality using a random-effects model. Five studies with 194 patients were included in the meta-analysis. Mortality was decreased for resection compared with biopsy at 6-months (RR 0.63 [95% CI 0.44–0.91]). No significant differences in overall survival were found at 12 (RR 0.76 [95% CI 0.50–1.14]) and 18-months (RR 0.84 [95% CI 0.56–1.26]). Surgical resection of bGBM is associated with an improved 6-months overall survival compared with biopsy alone. We have not found strong evidence supporting the superiority of resection over biopsy alone in overall survival at 12 and 18-months.Rafał ChojakMarta Koźba-GosztyłaKatarzyna SłychanDaniel GajosMarek KotasMichał TyliszczakBogdan CzapigaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rafał Chojak Marta Koźba-Gosztyła Katarzyna Słychan Daniel Gajos Marek Kotas Michał Tyliszczak Bogdan Czapiga Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies
description	Abstract Butterfly glioblastoma (bGBM) is a rare brain tumor that invades both hemispheres by crossing the corpus callosum. bGBM is associated with a dismal prognosis with a median survival time of a few months. Surgical resection is a rare treatment option due to the unfavorable location and assumed poor risk-to-benefit ratio. Therefore, a biopsy-alone approach is considered the main treatment option. This meta-analysis aimed to systematically evaluate whether resection of bGBM is associated with improved overall survival compared with biopsy alone. We searched three databases to find studies that compare resection with biopsy in 6-, 12- and 18-months overall survival in patients with bGBM. We calculated the pooled relative risk (RR) of mortality using a random-effects model. Five studies with 194 patients were included in the meta-analysis. Mortality was decreased for resection compared with biopsy at 6-months (RR 0.63 [95% CI 0.44–0.91]). No significant differences in overall survival were found at 12 (RR 0.76 [95% CI 0.50–1.14]) and 18-months (RR 0.84 [95% CI 0.56–1.26]). Surgical resection of bGBM is associated with an improved 6-months overall survival compared with biopsy alone. We have not found strong evidence supporting the superiority of resection over biopsy alone in overall survival at 12 and 18-months.
format	article
author	Rafał Chojak Marta Koźba-Gosztyła Katarzyna Słychan Daniel Gajos Marek Kotas Michał Tyliszczak Bogdan Czapiga
author_facet	Rafał Chojak Marta Koźba-Gosztyła Katarzyna Słychan Daniel Gajos Marek Kotas Michał Tyliszczak Bogdan Czapiga
author_sort	Rafał Chojak
title	Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies
title_short	Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies
title_full	Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies
title_fullStr	Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies
title_full_unstemmed	Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies
title_sort	impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7066e9dfaba548318981b962e59df58b
work_keys_str_mv	AT rafałchojak impactofsurgicalresectionofbutterflyglioblastomaonsurvivalametaanalysisbasedoncomparativestudies AT martakozbagosztyła impactofsurgicalresectionofbutterflyglioblastomaonsurvivalametaanalysisbasedoncomparativestudies AT katarzynasłychan impactofsurgicalresectionofbutterflyglioblastomaonsurvivalametaanalysisbasedoncomparativestudies AT danielgajos impactofsurgicalresectionofbutterflyglioblastomaonsurvivalametaanalysisbasedoncomparativestudies AT marekkotas impactofsurgicalresectionofbutterflyglioblastomaonsurvivalametaanalysisbasedoncomparativestudies AT michałtyliszczak impactofsurgicalresectionofbutterflyglioblastomaonsurvivalametaanalysisbasedoncomparativestudies AT bogdanczapiga impactofsurgicalresectionofbutterflyglioblastomaonsurvivalametaanalysisbasedoncomparativestudies
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Impact of surgical resection of butterfly glioblastoma on survival: a meta-analysis based on comparative studies

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