Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles

Objective: Alternative medicine plays an important role today in searching for therapeutics for cancer and viral infection. So, a scientific validation to characterize constituents in the alternative medicines and therapeutic testing is warranted using modern instrumentation. Methods: In the present...

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Autores principales:	Amirtham J.A. Ranjitsingh, Sandhanasamy Devanesan, Mohamad S. AlSalhi, Parameswari Paul, C. Padmalatha
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Herbomineral Kantha Rasavillai Nanoparticles Antiviral and anticancer Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/7067900a2a904f6b995f8e7b02a89745
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spelling	oai:doaj.org-article:7067900a2a904f6b995f8e7b02a897452021-11-22T04:18:40ZAntiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles1018-364710.1016/j.jksus.2021.101693https://doaj.org/article/7067900a2a904f6b995f8e7b02a897452022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003554https://doaj.org/toc/1018-3647Objective: Alternative medicine plays an important role today in searching for therapeutics for cancer and viral infection. So, a scientific validation to characterize constituents in the alternative medicines and therapeutic testing is warranted using modern instrumentation. Methods: In the present study, an old herbomineral formulation, KanthaRasavillai [KRV], was characterized using UV–vis spectrometry, FT-IR, XRD, SEM, and TEM study. Also, In vitro and in vivo studies were done to evaluate their antiviral and anticancer activity. FT-IR and XRD studies revealed a cocktail of nanoparticles of mercury, magnetic oxide, cinnabar, and arsenic.Results.Based on SEM, TEM, and XRD report, KRV contains nanoparticles in the size range of 9.1 nm to 25.0 nm. FT-IR analysis exposed the presence of several anti-cancerous bioactive compounds.Further in vitro testing against HCV virus proved KRV to inhibit HCV virus a close relative to SARS-CoV-2. MTT assay confirmed the anticancer effect of KRV against Huh-7 and MCF-7 cell lines. Conclusion: The anticancer and antiviral properties in the ancient herbomineral drug with a cocktail of metal nanoparticles acknowledge the traditional medical practice as a pioneering approach for present-day ailments. However, the study concludes that the use of KRV depends on safety dosage and genuine preparation as described by ancient saints.Amirtham J.A. RanjitsinghSandhanasamy DevanesanMohamad S. AlSalhiParameswari PaulC. PadmalathaElsevierarticleHerbomineralKantha RasavillaiNanoparticlesAntiviral and anticancerScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101693- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Herbomineral Kantha Rasavillai Nanoparticles Antiviral and anticancer Science (General) Q1-390
spellingShingle	Herbomineral Kantha Rasavillai Nanoparticles Antiviral and anticancer Science (General) Q1-390 Amirtham J.A. Ranjitsingh Sandhanasamy Devanesan Mohamad S. AlSalhi Parameswari Paul C. Padmalatha Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
description	Objective: Alternative medicine plays an important role today in searching for therapeutics for cancer and viral infection. So, a scientific validation to characterize constituents in the alternative medicines and therapeutic testing is warranted using modern instrumentation. Methods: In the present study, an old herbomineral formulation, KanthaRasavillai [KRV], was characterized using UV–vis spectrometry, FT-IR, XRD, SEM, and TEM study. Also, In vitro and in vivo studies were done to evaluate their antiviral and anticancer activity. FT-IR and XRD studies revealed a cocktail of nanoparticles of mercury, magnetic oxide, cinnabar, and arsenic.Results.Based on SEM, TEM, and XRD report, KRV contains nanoparticles in the size range of 9.1 nm to 25.0 nm. FT-IR analysis exposed the presence of several anti-cancerous bioactive compounds.Further in vitro testing against HCV virus proved KRV to inhibit HCV virus a close relative to SARS-CoV-2. MTT assay confirmed the anticancer effect of KRV against Huh-7 and MCF-7 cell lines. Conclusion: The anticancer and antiviral properties in the ancient herbomineral drug with a cocktail of metal nanoparticles acknowledge the traditional medical practice as a pioneering approach for present-day ailments. However, the study concludes that the use of KRV depends on safety dosage and genuine preparation as described by ancient saints.
format	article
author	Amirtham J.A. Ranjitsingh Sandhanasamy Devanesan Mohamad S. AlSalhi Parameswari Paul C. Padmalatha
author_facet	Amirtham J.A. Ranjitsingh Sandhanasamy Devanesan Mohamad S. AlSalhi Parameswari Paul C. Padmalatha
author_sort	Amirtham J.A. Ranjitsingh
title	Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
title_short	Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
title_full	Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
title_fullStr	Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
title_full_unstemmed	Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
title_sort	antiviral and cytotoxic effects of a traditional drug kantharasavillai with a cocktail of metallic nanoparticles
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/7067900a2a904f6b995f8e7b02a89745
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Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles

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