A population-specific reference panel for improved genotype imputation in African Americans

O’Connell et al. construct a new genome-wide imputation reference panel comprising 2,269 individuals of Sub-Saharan African ancestries. They adapt DeepVariant to create best practices for reference panel development and generate a high quality, publicly available resource that will further empower h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jared O’Connell, Taedong Yun, Meghan Moreno, Helen Li, Nadia Litterman, Alexey Kolesnikov, Elizabeth Noblin, Pi-Chuan Chang, Anjali Shastri, Elizabeth H. Dorfman, Suyash Shringarpure, 23andMe Research Team, Adam Auton, Andrew Carroll, Cory Y. McLean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7067eb24f89b44a79d3399694967a6d9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7067eb24f89b44a79d3399694967a6d9
record_format	dspace
spelling	oai:doaj.org-article:7067eb24f89b44a79d3399694967a6d92021-11-07T12:20:35ZA population-specific reference panel for improved genotype imputation in African Americans10.1038/s42003-021-02777-92399-3642https://doaj.org/article/7067eb24f89b44a79d3399694967a6d92021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02777-9https://doaj.org/toc/2399-3642O’Connell et al. construct a new genome-wide imputation reference panel comprising 2,269 individuals of Sub-Saharan African ancestries. They adapt DeepVariant to create best practices for reference panel development and generate a high quality, publicly available resource that will further empower high resolution genome-wide imputation efforts in individuals of African ancestries.Jared O’ConnellTaedong YunMeghan MorenoHelen LiNadia LittermanAlexey KolesnikovElizabeth NoblinPi-Chuan ChangAnjali ShastriElizabeth H. DorfmanSuyash Shringarpure23andMe Research TeamAdam AutonAndrew CarrollCory Y. McLeanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jared O’Connell Taedong Yun Meghan Moreno Helen Li Nadia Litterman Alexey Kolesnikov Elizabeth Noblin Pi-Chuan Chang Anjali Shastri Elizabeth H. Dorfman Suyash Shringarpure 23andMe Research Team Adam Auton Andrew Carroll Cory Y. McLean A population-specific reference panel for improved genotype imputation in African Americans
description	O’Connell et al. construct a new genome-wide imputation reference panel comprising 2,269 individuals of Sub-Saharan African ancestries. They adapt DeepVariant to create best practices for reference panel development and generate a high quality, publicly available resource that will further empower high resolution genome-wide imputation efforts in individuals of African ancestries.
format	article
author	Jared O’Connell Taedong Yun Meghan Moreno Helen Li Nadia Litterman Alexey Kolesnikov Elizabeth Noblin Pi-Chuan Chang Anjali Shastri Elizabeth H. Dorfman Suyash Shringarpure 23andMe Research Team Adam Auton Andrew Carroll Cory Y. McLean
author_facet	Jared O’Connell Taedong Yun Meghan Moreno Helen Li Nadia Litterman Alexey Kolesnikov Elizabeth Noblin Pi-Chuan Chang Anjali Shastri Elizabeth H. Dorfman Suyash Shringarpure 23andMe Research Team Adam Auton Andrew Carroll Cory Y. McLean
author_sort	Jared O’Connell
title	A population-specific reference panel for improved genotype imputation in African Americans
title_short	A population-specific reference panel for improved genotype imputation in African Americans
title_full	A population-specific reference panel for improved genotype imputation in African Americans
title_fullStr	A population-specific reference panel for improved genotype imputation in African Americans
title_full_unstemmed	A population-specific reference panel for improved genotype imputation in African Americans
title_sort	population-specific reference panel for improved genotype imputation in african americans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7067eb24f89b44a79d3399694967a6d9
work_keys_str_mv	AT jaredoconnell apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT taedongyun apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT meghanmoreno apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT helenli apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT nadialitterman apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT alexeykolesnikov apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT elizabethnoblin apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT pichuanchang apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT anjalishastri apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT elizabethhdorfman apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT suyashshringarpure apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT 23andmeresearchteam apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT adamauton apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT andrewcarroll apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT coryymclean apopulationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT jaredoconnell populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT taedongyun populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT meghanmoreno populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT helenli populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT nadialitterman populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT alexeykolesnikov populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT elizabethnoblin populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT pichuanchang populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT anjalishastri populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT elizabethhdorfman populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT suyashshringarpure populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT 23andmeresearchteam populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT adamauton populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT andrewcarroll populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans AT coryymclean populationspecificreferencepanelforimprovedgenotypeimputationinafricanamericans
_version_	1718443494499942400

A population-specific reference panel for improved genotype imputation in African Americans

Ejemplares similares