The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation

Histones are recognized by epigenetic readers, which play essential roles in regulation of chromatin and transcription. Here the authors provide evidence that the ZZ-type zinc finger domain of ZZZ3 functions as a reader of histone H3, which is required for the ATAC complex-mediated maintenance of hi...

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Autores principales: Wenyi Mi, Yi Zhang, Jie Lyu, Xiaolu Wang, Qiong Tong, Danni Peng, Yongming Xue, Adam H. Tencer, Hong Wen, Wei Li, Tatiana G. Kutateladze, Xiaobing Shi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/706d64407518422684bb8fdcea8f4a58
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Sumario:Histones are recognized by epigenetic readers, which play essential roles in regulation of chromatin and transcription. Here the authors provide evidence that the ZZ-type zinc finger domain of ZZZ3 functions as a reader of histone H3, which is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation.