Janus-Faced Molecules against Plant Pathogenic Fungi

The high cytotoxicity of the secondary metabolites of mycotoxins is capable of killing microbes and tumour cells alike, similarly to the genotoxic effect characteristic of Janus-faced molecules. The “double-edged sword” effect of several cytotoxins is known, and these agents have, therefore, been ut...

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Autor principal:	Gaspar Banfalvi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mycotoxins classification of carcinogens animal models agents against plant mycoses structure–function relationship Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/706f0abec3314cab8eb69bde60d78708
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id	oai:doaj.org-article:706f0abec3314cab8eb69bde60d78708
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spelling	oai:doaj.org-article:706f0abec3314cab8eb69bde60d787082021-11-25T17:55:24ZJanus-Faced Molecules against Plant Pathogenic Fungi10.3390/ijms2222123231422-00671661-6596https://doaj.org/article/706f0abec3314cab8eb69bde60d787082021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12323https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The high cytotoxicity of the secondary metabolites of mycotoxins is capable of killing microbes and tumour cells alike, similarly to the genotoxic effect characteristic of Janus-faced molecules. The “double-edged sword” effect of several cytotoxins is known, and these agents have, therefore, been utilized only reluctantly against fungal infections. In this review, consideration was given to (a) toxins that could be used against plant and human pathogens, (b) animal models that measure the effect of antifungal agents, (c) known antifungal agents that have been described and efficiently prevent the growth of fungal cells, and (d) the chemical interactions that are characteristic of antifungal agents. The utilization of apoptotic effects against tumour growth by agents that, at the same time, induce mutations may raise ethical issues. Nevertheless, it deserves consideration despite the mutagenic impact of Janus-faced molecules for those patients who suffer from plant pathogenic fungal infections and are older than their fertility age, in the same way that the short-term cytotoxicity of cancer treatment is favoured over the long-term mutagenic effect.Gaspar BanfalviMDPI AGarticlemycotoxinsclassification of carcinogensanimal modelsagents against plant mycosesstructure–function relationshipBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12323, p 12323 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mycotoxins classification of carcinogens animal models agents against plant mycoses structure–function relationship Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mycotoxins classification of carcinogens animal models agents against plant mycoses structure–function relationship Biology (General) QH301-705.5 Chemistry QD1-999 Gaspar Banfalvi Janus-Faced Molecules against Plant Pathogenic Fungi
description	The high cytotoxicity of the secondary metabolites of mycotoxins is capable of killing microbes and tumour cells alike, similarly to the genotoxic effect characteristic of Janus-faced molecules. The “double-edged sword” effect of several cytotoxins is known, and these agents have, therefore, been utilized only reluctantly against fungal infections. In this review, consideration was given to (a) toxins that could be used against plant and human pathogens, (b) animal models that measure the effect of antifungal agents, (c) known antifungal agents that have been described and efficiently prevent the growth of fungal cells, and (d) the chemical interactions that are characteristic of antifungal agents. The utilization of apoptotic effects against tumour growth by agents that, at the same time, induce mutations may raise ethical issues. Nevertheless, it deserves consideration despite the mutagenic impact of Janus-faced molecules for those patients who suffer from plant pathogenic fungal infections and are older than their fertility age, in the same way that the short-term cytotoxicity of cancer treatment is favoured over the long-term mutagenic effect.
format	article
author	Gaspar Banfalvi
author_facet	Gaspar Banfalvi
author_sort	Gaspar Banfalvi
title	Janus-Faced Molecules against Plant Pathogenic Fungi
title_short	Janus-Faced Molecules against Plant Pathogenic Fungi
title_full	Janus-Faced Molecules against Plant Pathogenic Fungi
title_fullStr	Janus-Faced Molecules against Plant Pathogenic Fungi
title_full_unstemmed	Janus-Faced Molecules against Plant Pathogenic Fungi
title_sort	janus-faced molecules against plant pathogenic fungi
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/706f0abec3314cab8eb69bde60d78708
work_keys_str_mv	AT gasparbanfalvi janusfacedmoleculesagainstplantpathogenicfungi
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Janus-Faced Molecules against Plant Pathogenic Fungi

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