Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells

A tumour’s cell of origin may influence tumour progression and response to therapy. Here, the authors demonstrate that the cell of origin determines the aggressiveness of AML in a mouse model and identify unique biomarkers of the specific leukaemia cell of origin by profiling open chromatin regions...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joshy George, Asli Uyar, Kira Young, Lauren Kuffler, Kaiden Waldron-Francis, Eladio Marquez, Duygu Ucar, Jennifer J. Trowbridge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70722a88da604d20ab0f1850c071e8ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70722a88da604d20ab0f1850c071e8ca
record_format	dspace
spelling	oai:doaj.org-article:70722a88da604d20ab0f1850c071e8ca2021-12-02T16:56:45ZLeukaemia cell of origin identified by chromatin landscape of bulk tumour cells10.1038/ncomms121662041-1723https://doaj.org/article/70722a88da604d20ab0f1850c071e8ca2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12166https://doaj.org/toc/2041-1723A tumour’s cell of origin may influence tumour progression and response to therapy. Here, the authors demonstrate that the cell of origin determines the aggressiveness of AML in a mouse model and identify unique biomarkers of the specific leukaemia cell of origin by profiling open chromatin regions of AML samples.Joshy GeorgeAsli UyarKira YoungLauren KufflerKaiden Waldron-FrancisEladio MarquezDuygu UcarJennifer J. TrowbridgeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshy George Asli Uyar Kira Young Lauren Kuffler Kaiden Waldron-Francis Eladio Marquez Duygu Ucar Jennifer J. Trowbridge Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
description	A tumour’s cell of origin may influence tumour progression and response to therapy. Here, the authors demonstrate that the cell of origin determines the aggressiveness of AML in a mouse model and identify unique biomarkers of the specific leukaemia cell of origin by profiling open chromatin regions of AML samples.
format	article
author	Joshy George Asli Uyar Kira Young Lauren Kuffler Kaiden Waldron-Francis Eladio Marquez Duygu Ucar Jennifer J. Trowbridge
author_facet	Joshy George Asli Uyar Kira Young Lauren Kuffler Kaiden Waldron-Francis Eladio Marquez Duygu Ucar Jennifer J. Trowbridge
author_sort	Joshy George
title	Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
title_short	Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
title_full	Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
title_fullStr	Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
title_full_unstemmed	Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
title_sort	leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/70722a88da604d20ab0f1850c071e8ca
work_keys_str_mv	AT joshygeorge leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells AT asliuyar leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells AT kirayoung leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells AT laurenkuffler leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells AT kaidenwaldronfrancis leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells AT eladiomarquez leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells AT duyguucar leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells AT jenniferjtrowbridge leukaemiacelloforiginidentifiedbychromatinlandscapeofbulktumourcells
_version_	1718382744709365760

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells

Ejemplares similares