Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.

Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting a...

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Autores principales:	Daniel Sauter, Frank Kirchhoff
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7076294ccbf04b95b0f2fe6213b5c9da
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spelling	oai:doaj.org-article:7076294ccbf04b95b0f2fe6213b5c9da2021-12-02T19:54:37ZLess is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.1544-91731545-788510.1371/journal.pbio.3001353https://doaj.org/article/7076294ccbf04b95b0f2fe6213b5c9da2021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001353https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.Daniel SauterFrank KirchhoffPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 9, p e3001353 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Daniel Sauter Frank Kirchhoff Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
description	Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.
format	article
author	Daniel Sauter Frank Kirchhoff
author_facet	Daniel Sauter Frank Kirchhoff
author_sort	Daniel Sauter
title	Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
title_short	Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
title_full	Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
title_fullStr	Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
title_full_unstemmed	Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
title_sort	less is more: biased loss of cpg dinucleotides strengthens antiviral immunity.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7076294ccbf04b95b0f2fe6213b5c9da
work_keys_str_mv	AT danielsauter lessismorebiasedlossofcpgdinucleotidesstrengthensantiviralimmunity AT frankkirchhoff lessismorebiasedlossofcpgdinucleotidesstrengthensantiviralimmunity
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Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.

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