Engineered clearing agents for the selective depletion of antigen-specific antibodies

The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to deplete MOG- and HER2-specific antibodies in mice....

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Auteurs principaux:	Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober, E. Sally Ward
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c
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id	oai:doaj.org-article:7077cda82f6d4593beeed48ce19dff2c
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spelling	oai:doaj.org-article:7077cda82f6d4593beeed48ce19dff2c2021-12-02T17:06:22ZEngineered clearing agents for the selective depletion of antigen-specific antibodies10.1038/ncomms153142041-1723https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15314https://doaj.org/toc/2041-1723The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to deplete MOG- and HER2-specific antibodies in mice.Siva Charan DevanaboyinaPriyanka KhareDilip K. ChallaRaimund J. OberE. Sally WardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siva Charan Devanaboyina Priyanka Khare Dilip K. Challa Raimund J. Ober E. Sally Ward Engineered clearing agents for the selective depletion of antigen-specific antibodies
description	The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to deplete MOG- and HER2-specific antibodies in mice.
format	article
author	Siva Charan Devanaboyina Priyanka Khare Dilip K. Challa Raimund J. Ober E. Sally Ward
author_facet	Siva Charan Devanaboyina Priyanka Khare Dilip K. Challa Raimund J. Ober E. Sally Ward
author_sort	Siva Charan Devanaboyina
title	Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_short	Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_full	Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_fullStr	Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_full_unstemmed	Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_sort	engineered clearing agents for the selective depletion of antigen-specific antibodies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c
work_keys_str_mv	AT sivacharandevanaboyina engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies AT priyankakhare engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies AT dilipkchalla engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies AT raimundjober engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies AT esallyward engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies
_version_	1718381617634869248

Engineered clearing agents for the selective depletion of antigen-specific antibodies

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