Engineered clearing agents for the selective depletion of antigen-specific antibodies

The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to deplete MOG- and HER2-specific antibodies in mice....

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Autores principales: Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober, E. Sally Ward
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c
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spelling oai:doaj.org-article:7077cda82f6d4593beeed48ce19dff2c2021-12-02T17:06:22ZEngineered clearing agents for the selective depletion of antigen-specific antibodies10.1038/ncomms153142041-1723https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15314https://doaj.org/toc/2041-1723The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to deplete MOG- and HER2-specific antibodies in mice.Siva Charan DevanaboyinaPriyanka KhareDilip K. ChallaRaimund J. OberE. Sally WardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Siva Charan Devanaboyina
Priyanka Khare
Dilip K. Challa
Raimund J. Ober
E. Sally Ward
Engineered clearing agents for the selective depletion of antigen-specific antibodies
description The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to deplete MOG- and HER2-specific antibodies in mice.
format article
author Siva Charan Devanaboyina
Priyanka Khare
Dilip K. Challa
Raimund J. Ober
E. Sally Ward
author_facet Siva Charan Devanaboyina
Priyanka Khare
Dilip K. Challa
Raimund J. Ober
E. Sally Ward
author_sort Siva Charan Devanaboyina
title Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_short Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_full Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_fullStr Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_full_unstemmed Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_sort engineered clearing agents for the selective depletion of antigen-specific antibodies
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c
work_keys_str_mv AT sivacharandevanaboyina engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies
AT priyankakhare engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies
AT dilipkchalla engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies
AT raimundjober engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies
AT esallyward engineeredclearingagentsfortheselectivedepletionofantigenspecificantibodies
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