Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin

Abstract In this work, a novel nanosensing platform was suggested based on ruthenium for the sensitive determination of Idarubicin anticancer drugs. Ruthenium/Vulcan carbon-based nanoparticles were synthesized ultrasonication method and then characterized by transmission electron microscopy (TEM), X...

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Autores principales:	S. Irem Kaya, Sevinc Kurbanoglu, Ejmer Yavuz, Sibel Demiroglu Mustafov, Fatih Sen, Sibel A. Ozkan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/707953346d7040288c075841c0863e89
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spelling	oai:doaj.org-article:707953346d7040288c075841c0863e892021-12-02T15:39:49ZCarbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin10.1038/s41598-020-68055-62045-2322https://doaj.org/article/707953346d7040288c075841c0863e892020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68055-6https://doaj.org/toc/2045-2322Abstract In this work, a novel nanosensing platform was suggested based on ruthenium for the sensitive determination of Idarubicin anticancer drugs. Ruthenium/Vulcan carbon-based nanoparticles were synthesized ultrasonication method and then characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The mean particle size of the nanoparticles calculated by the TEM analysis was found to be 1.98 nm ± 0.29 nm, and the Ru nanoparticles were mostly dispersed on the support material. Glassy carbon electrode (GCE) surface was modified with Ruthenium/Vulcan carbon-based nanomaterials (Ru@VC), and characterization of the nanosensor was performed using electrochemical impedance spectroscopy and cyclic voltammetry. The limit of detection (LOD) and limit of quantification (LOQ) values were found as 9.25 × 10–9 M and 2.8 × 10–8 M in buffer samples. To demonstrate the applicability and validity of developed nanosensor, it was used for the determination of Idarubicin in Idamen® IV (10 mg/10 mL vial) and human serum sample. The results of recovery studies showed that the Ru@VC/GCE nanosensor was free from excipient interferences in the dosage forms of injection, and it can be successfully applied to biological samples.S. Irem KayaSevinc KurbanogluEjmer YavuzSibel Demiroglu MustafovFatih SenSibel A. OzkanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. Irem Kaya Sevinc Kurbanoglu Ejmer Yavuz Sibel Demiroglu Mustafov Fatih Sen Sibel A. Ozkan Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
description	Abstract In this work, a novel nanosensing platform was suggested based on ruthenium for the sensitive determination of Idarubicin anticancer drugs. Ruthenium/Vulcan carbon-based nanoparticles were synthesized ultrasonication method and then characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The mean particle size of the nanoparticles calculated by the TEM analysis was found to be 1.98 nm ± 0.29 nm, and the Ru nanoparticles were mostly dispersed on the support material. Glassy carbon electrode (GCE) surface was modified with Ruthenium/Vulcan carbon-based nanomaterials (Ru@VC), and characterization of the nanosensor was performed using electrochemical impedance spectroscopy and cyclic voltammetry. The limit of detection (LOD) and limit of quantification (LOQ) values were found as 9.25 × 10–9 M and 2.8 × 10–8 M in buffer samples. To demonstrate the applicability and validity of developed nanosensor, it was used for the determination of Idarubicin in Idamen® IV (10 mg/10 mL vial) and human serum sample. The results of recovery studies showed that the Ru@VC/GCE nanosensor was free from excipient interferences in the dosage forms of injection, and it can be successfully applied to biological samples.
format	article
author	S. Irem Kaya Sevinc Kurbanoglu Ejmer Yavuz Sibel Demiroglu Mustafov Fatih Sen Sibel A. Ozkan
author_facet	S. Irem Kaya Sevinc Kurbanoglu Ejmer Yavuz Sibel Demiroglu Mustafov Fatih Sen Sibel A. Ozkan
author_sort	S. Irem Kaya
title	Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_short	Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_full	Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_fullStr	Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_full_unstemmed	Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_sort	carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug idarubicin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/707953346d7040288c075841c0863e89
work_keys_str_mv	AT siremkaya carbonbasedrutheniumnanomaterialbasedelectroanalyticalsensorsforthedetectionofanticancerdrugidarubicin AT sevinckurbanoglu carbonbasedrutheniumnanomaterialbasedelectroanalyticalsensorsforthedetectionofanticancerdrugidarubicin AT ejmeryavuz carbonbasedrutheniumnanomaterialbasedelectroanalyticalsensorsforthedetectionofanticancerdrugidarubicin AT sibeldemiroglumustafov carbonbasedrutheniumnanomaterialbasedelectroanalyticalsensorsforthedetectionofanticancerdrugidarubicin AT fatihsen carbonbasedrutheniumnanomaterialbasedelectroanalyticalsensorsforthedetectionofanticancerdrugidarubicin AT sibelaozkan carbonbasedrutheniumnanomaterialbasedelectroanalyticalsensorsforthedetectionofanticancerdrugidarubicin
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Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin

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