Memory recall involves a transient break in excitatory-inhibitory balance

The brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that su...

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Autores principales:	Renée S Koolschijn, Anna Shpektor, William T Clarke, I Betina Ip, David Dupret, Uzay E Emir, Helen C Barron
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	hippocampus excitatory-inhibitory balance hippocampal-cortical interactions fMRS fMRI memory Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/707e79d6dab0477d9a29972892cf64d7
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id	oai:doaj.org-article:707e79d6dab0477d9a29972892cf64d7
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spelling	oai:doaj.org-article:707e79d6dab0477d9a29972892cf64d72021-12-01T10:54:19ZMemory recall involves a transient break in excitatory-inhibitory balance10.7554/eLife.700712050-084Xe70071https://doaj.org/article/707e79d6dab0477d9a29972892cf64d72021-10-01T00:00:00Zhttps://elifesciences.org/articles/70071https://doaj.org/toc/2050-084XThe brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that supports this interaction remains unclear. Here, in humans, we show that recall of a visual cue from a paired associate is accompanied by a transient increase in the ratio between glutamate and GABA in visual cortex. Moreover, these excitatory-inhibitory fluctuations are predicted by activity in the hippocampus. These data suggest the hippocampus gates memory recall by indexing information stored across neocortical circuits using a disinhibitory mechanism.Renée S KoolschijnAnna ShpektorWilliam T ClarkeI Betina IpDavid DupretUzay E EmirHelen C BarroneLife Sciences Publications Ltdarticlehippocampusexcitatory-inhibitory balancehippocampal-cortical interactionsfMRSfMRImemoryMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hippocampus excitatory-inhibitory balance hippocampal-cortical interactions fMRS fMRI memory Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	hippocampus excitatory-inhibitory balance hippocampal-cortical interactions fMRS fMRI memory Medicine R Science Q Biology (General) QH301-705.5 Renée S Koolschijn Anna Shpektor William T Clarke I Betina Ip David Dupret Uzay E Emir Helen C Barron Memory recall involves a transient break in excitatory-inhibitory balance
description	The brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that supports this interaction remains unclear. Here, in humans, we show that recall of a visual cue from a paired associate is accompanied by a transient increase in the ratio between glutamate and GABA in visual cortex. Moreover, these excitatory-inhibitory fluctuations are predicted by activity in the hippocampus. These data suggest the hippocampus gates memory recall by indexing information stored across neocortical circuits using a disinhibitory mechanism.
format	article
author	Renée S Koolschijn Anna Shpektor William T Clarke I Betina Ip David Dupret Uzay E Emir Helen C Barron
author_facet	Renée S Koolschijn Anna Shpektor William T Clarke I Betina Ip David Dupret Uzay E Emir Helen C Barron
author_sort	Renée S Koolschijn
title	Memory recall involves a transient break in excitatory-inhibitory balance
title_short	Memory recall involves a transient break in excitatory-inhibitory balance
title_full	Memory recall involves a transient break in excitatory-inhibitory balance
title_fullStr	Memory recall involves a transient break in excitatory-inhibitory balance
title_full_unstemmed	Memory recall involves a transient break in excitatory-inhibitory balance
title_sort	memory recall involves a transient break in excitatory-inhibitory balance
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/707e79d6dab0477d9a29972892cf64d7
work_keys_str_mv	AT reneeskoolschijn memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT annashpektor memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT williamtclarke memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT ibetinaip memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT daviddupret memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT uzayeemir memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT helencbarron memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance
_version_	1718405239129767936

Memory recall involves a transient break in excitatory-inhibitory balance

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