Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy

Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation. Our...

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Autores principales:	Mingzhu Chen, Ziqi Wang, Weilong Suo, Zhirong Bao, Hong Quan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	FeGa fenton reaction radiotherapy hydrogel tumor therapy Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/707f2f9b9a02486f9a79cedac5a2fb5a
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spelling	oai:doaj.org-article:707f2f9b9a02486f9a79cedac5a2fb5a2021-11-22T06:40:12ZInjectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy2296-418510.3389/fbioe.2021.757428https://doaj.org/article/707f2f9b9a02486f9a79cedac5a2fb5a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.757428/fullhttps://doaj.org/toc/2296-4185Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation. Our FH can deliver FeGA directly to the tumor site via intratumoral injection, where it is a reservoir-based system to conserve FeGA. The photothermal properties of FeGA steadily dissolve FH under laser irradiation, and, simultaneously, FeGA reacts with a large amount of H2O2 in the cell to produce OH (Fenton reaction) which is highly toxic to mitochondria, rendering the cell inactive and reducing radiotherapy resistance. In vivo and in vitro studies suggest that combining the FH and NIR irradiation with RT (2Gy) can significantly reduce tumor proliferation without side effects such as inflammation. To conclude, this is the first study to achieve combined chemodynamic therapy (CDT) and photothermal therapy (PTT) in situ treatment, and the best therapeutic effect can be obtained with a low-dose radiation combination, thus expanding the prospects of FeGA-based tumor therapy.Mingzhu ChenZiqi WangWeilong SuoZhirong BaoHong QuanFrontiers Media S.A.articleFeGafenton reactionradiotherapyhydrogeltumor therapyBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FeGa fenton reaction radiotherapy hydrogel tumor therapy Biotechnology TP248.13-248.65
spellingShingle	FeGa fenton reaction radiotherapy hydrogel tumor therapy Biotechnology TP248.13-248.65 Mingzhu Chen Ziqi Wang Weilong Suo Zhirong Bao Hong Quan Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
description	Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation. Our FH can deliver FeGA directly to the tumor site via intratumoral injection, where it is a reservoir-based system to conserve FeGA. The photothermal properties of FeGA steadily dissolve FH under laser irradiation, and, simultaneously, FeGA reacts with a large amount of H2O2 in the cell to produce OH (Fenton reaction) which is highly toxic to mitochondria, rendering the cell inactive and reducing radiotherapy resistance. In vivo and in vitro studies suggest that combining the FH and NIR irradiation with RT (2Gy) can significantly reduce tumor proliferation without side effects such as inflammation. To conclude, this is the first study to achieve combined chemodynamic therapy (CDT) and photothermal therapy (PTT) in situ treatment, and the best therapeutic effect can be obtained with a low-dose radiation combination, thus expanding the prospects of FeGA-based tumor therapy.
format	article
author	Mingzhu Chen Ziqi Wang Weilong Suo Zhirong Bao Hong Quan
author_facet	Mingzhu Chen Ziqi Wang Weilong Suo Zhirong Bao Hong Quan
author_sort	Mingzhu Chen
title	Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
title_short	Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
title_full	Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
title_fullStr	Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
title_full_unstemmed	Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
title_sort	injectable hydrogel for synergetic low dose radiotherapy, chemodynamic therapy and photothermal therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/707f2f9b9a02486f9a79cedac5a2fb5a
work_keys_str_mv	AT mingzhuchen injectablehydrogelforsynergeticlowdoseradiotherapychemodynamictherapyandphotothermaltherapy AT ziqiwang injectablehydrogelforsynergeticlowdoseradiotherapychemodynamictherapyandphotothermaltherapy AT weilongsuo injectablehydrogelforsynergeticlowdoseradiotherapychemodynamictherapyandphotothermaltherapy AT zhirongbao injectablehydrogelforsynergeticlowdoseradiotherapychemodynamictherapyandphotothermaltherapy AT hongquan injectablehydrogelforsynergeticlowdoseradiotherapychemodynamictherapyandphotothermaltherapy
_version_	1718418108609200128

Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy

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