Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

The enterotoxins TcdA and TcdB induce cytotoxicity of epithelial cells during Clostridium difficile infection. Here the authors show that bacterial induced epithelial cell death occurs via activation of caspases 3 and 7, resulting in apoptotic cell death.

Guardado en:

Detalles Bibliográficos
Autores principales:	Pedro H. V. Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/708354e64dcb42588aa6882947904dbf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:708354e64dcb42588aa6882947904dbf
record_format	dspace
spelling	oai:doaj.org-article:708354e64dcb42588aa6882947904dbf2021-12-02T14:39:26ZApoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis10.1038/s41467-018-07386-52041-1723https://doaj.org/article/708354e64dcb42588aa6882947904dbf2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07386-5https://doaj.org/toc/2041-1723The enterotoxins TcdA and TcdB induce cytotoxicity of epithelial cells during Clostridium difficile infection. Here the authors show that bacterial induced epithelial cell death occurs via activation of caspases 3 and 7, resulting in apoptotic cell death.Pedro H. V. SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed LamkanfiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pedro H. V. Saavedra Linyan Huang Farzaneh Ghazavi Stephanie Kourula Tom Vanden Berghe Nozomi Takahashi Peter Vandenabeele Mohamed Lamkanfi Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
description	The enterotoxins TcdA and TcdB induce cytotoxicity of epithelial cells during Clostridium difficile infection. Here the authors show that bacterial induced epithelial cell death occurs via activation of caspases 3 and 7, resulting in apoptotic cell death.
format	article
author	Pedro H. V. Saavedra Linyan Huang Farzaneh Ghazavi Stephanie Kourula Tom Vanden Berghe Nozomi Takahashi Peter Vandenabeele Mohamed Lamkanfi
author_facet	Pedro H. V. Saavedra Linyan Huang Farzaneh Ghazavi Stephanie Kourula Tom Vanden Berghe Nozomi Takahashi Peter Vandenabeele Mohamed Lamkanfi
author_sort	Pedro H. V. Saavedra
title	Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_short	Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_full	Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_fullStr	Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_full_unstemmed	Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_sort	apoptosis of intestinal epithelial cells restricts clostridium difficile infection in a model of pseudomembranous colitis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/708354e64dcb42588aa6882947904dbf
work_keys_str_mv	AT pedrohvsaavedra apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis AT linyanhuang apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis AT farzanehghazavi apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis AT stephaniekourula apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis AT tomvandenberghe apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis AT nozomitakahashi apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis AT petervandenabeele apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis AT mohamedlamkanfi apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
_version_	1718390598116835328

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Ejemplares similares