Genetic variation in virulence among chalkbrood strains infecting honeybees.

Ascosphaera apis causes chalkbrood in honeybees, a chronic disease that reduces the number of viable offspring in the nest. Although lethal for larvae, the disease normally has relatively low virulence at the colony level. A recent study showed that there is genetic variation for host susceptibility...

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Autores principales:	Svjetlana Vojvodic, Annette B Jensen, Bo Markussen, Jørgen Eilenberg, Jacobus J Boomsma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/708357e61da34bb59dacbff8b90b7f85
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spelling	oai:doaj.org-article:708357e61da34bb59dacbff8b90b7f852021-11-04T06:08:01ZGenetic variation in virulence among chalkbrood strains infecting honeybees.1932-620310.1371/journal.pone.0025035https://doaj.org/article/708357e61da34bb59dacbff8b90b7f852011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966406/?tool=EBIhttps://doaj.org/toc/1932-6203Ascosphaera apis causes chalkbrood in honeybees, a chronic disease that reduces the number of viable offspring in the nest. Although lethal for larvae, the disease normally has relatively low virulence at the colony level. A recent study showed that there is genetic variation for host susceptibility, but whether Ascosphaera apis strains differ in virulence is unknown. We exploited a recently modified in vitro rearing technique to infect honeybee larvae from three colonies with naturally mated queens under strictly controlled laboratory conditions, using four strains from two distinct A. apis clades. We found that both strain and colony of larval origin affected mortality rates. The strains from one clade caused 12-14% mortality while those from the other clade induced 71-92% mortality. Larvae from one colony showed significantly higher susceptibility to chalkbrood infection than larvae from the other two colonies, confirming the existence of genetic variation in susceptibility across colonies. Our results are consistent with antagonistic coevolution between a specialized fungal pathogen and its host, and suggest that beekeeping industries would benefit from more systematic monitoring of this chronic stress factor of their colonies.Svjetlana VojvodicAnnette B JensenBo MarkussenJørgen EilenbergJacobus J BoomsmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e25035 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Svjetlana Vojvodic Annette B Jensen Bo Markussen Jørgen Eilenberg Jacobus J Boomsma Genetic variation in virulence among chalkbrood strains infecting honeybees.
description	Ascosphaera apis causes chalkbrood in honeybees, a chronic disease that reduces the number of viable offspring in the nest. Although lethal for larvae, the disease normally has relatively low virulence at the colony level. A recent study showed that there is genetic variation for host susceptibility, but whether Ascosphaera apis strains differ in virulence is unknown. We exploited a recently modified in vitro rearing technique to infect honeybee larvae from three colonies with naturally mated queens under strictly controlled laboratory conditions, using four strains from two distinct A. apis clades. We found that both strain and colony of larval origin affected mortality rates. The strains from one clade caused 12-14% mortality while those from the other clade induced 71-92% mortality. Larvae from one colony showed significantly higher susceptibility to chalkbrood infection than larvae from the other two colonies, confirming the existence of genetic variation in susceptibility across colonies. Our results are consistent with antagonistic coevolution between a specialized fungal pathogen and its host, and suggest that beekeeping industries would benefit from more systematic monitoring of this chronic stress factor of their colonies.
format	article
author	Svjetlana Vojvodic Annette B Jensen Bo Markussen Jørgen Eilenberg Jacobus J Boomsma
author_facet	Svjetlana Vojvodic Annette B Jensen Bo Markussen Jørgen Eilenberg Jacobus J Boomsma
author_sort	Svjetlana Vojvodic
title	Genetic variation in virulence among chalkbrood strains infecting honeybees.
title_short	Genetic variation in virulence among chalkbrood strains infecting honeybees.
title_full	Genetic variation in virulence among chalkbrood strains infecting honeybees.
title_fullStr	Genetic variation in virulence among chalkbrood strains infecting honeybees.
title_full_unstemmed	Genetic variation in virulence among chalkbrood strains infecting honeybees.
title_sort	genetic variation in virulence among chalkbrood strains infecting honeybees.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/708357e61da34bb59dacbff8b90b7f85
work_keys_str_mv	AT svjetlanavojvodic geneticvariationinvirulenceamongchalkbroodstrainsinfectinghoneybees AT annettebjensen geneticvariationinvirulenceamongchalkbroodstrainsinfectinghoneybees AT bomarkussen geneticvariationinvirulenceamongchalkbroodstrainsinfectinghoneybees AT jørgeneilenberg geneticvariationinvirulenceamongchalkbroodstrainsinfectinghoneybees AT jacobusjboomsma geneticvariationinvirulenceamongchalkbroodstrainsinfectinghoneybees
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Genetic variation in virulence among chalkbrood strains infecting honeybees.

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