Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults

Abstract Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the...

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Autores principales:	Lingxiao He, John E. Morley, Geetika Aggarwal, Andrew D. Nguyen, Bruno Vellas, Philipe de Souto Barreto, the MAPT/DSA Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7088dec790fc4066a1ece005c7ffac11
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spelling	oai:doaj.org-article:7088dec790fc4066a1ece005c7ffac112021-12-02T18:18:44ZPlasma neurofilament light chain is associated with cognitive decline in non-dementia older adults10.1038/s41598-021-91038-02045-2322https://doaj.org/article/7088dec790fc4066a1ece005c7ffac112021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91038-0https://doaj.org/toc/2045-2322Abstract Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β = − 0.007, 95% CI [− 0.013, − 0.001]; CCS: β = − 0.003, 95% CI [− 0.006, − 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β = − 0.003, 95% CI [− 0.005, − 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β = − 0.07, 95% CI [− 0.12, − 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.Lingxiao HeJohn E. MorleyGeetika AggarwalAndrew D. NguyenBruno VellasPhilipe de Souto Barretothe MAPT/DSA GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingxiao He John E. Morley Geetika Aggarwal Andrew D. Nguyen Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
description	Abstract Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β = − 0.007, 95% CI [− 0.013, − 0.001]; CCS: β = − 0.003, 95% CI [− 0.006, − 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β = − 0.003, 95% CI [− 0.005, − 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β = − 0.07, 95% CI [− 0.12, − 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.
format	article
author	Lingxiao He John E. Morley Geetika Aggarwal Andrew D. Nguyen Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group
author_facet	Lingxiao He John E. Morley Geetika Aggarwal Andrew D. Nguyen Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group
author_sort	Lingxiao He
title	Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
title_short	Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
title_full	Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
title_fullStr	Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
title_full_unstemmed	Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
title_sort	plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7088dec790fc4066a1ece005c7ffac11
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Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults

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