Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study

A group of coagulase-negative staphylococci (CoNS) was historically classified as a nonpathogenic bacteria. Over the last few decades, nosocomial infections caused by CoNS as opportunistic pathogens have increased and become one of the major nosocomial pathogens. The aim of this study was to identif...

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Autores principales:	Herleeyana Meriyani, Dwi Arymbhi Sanjaya, Ketut Agus Adrianta
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	antibiotic consumption, antibiotic resistance, ecological study, cons Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/70924e356cd34a9fbb0dc01a6512ac4e
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spelling	oai:doaj.org-article:70924e356cd34a9fbb0dc01a6512ac4e2021-11-15T06:08:46ZAntibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study2338-94272338-948610.22146/ijp.1154https://doaj.org/article/70924e356cd34a9fbb0dc01a6512ac4e2021-06-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1154https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486A group of coagulase-negative staphylococci (CoNS) was historically classified as a nonpathogenic bacteria. Over the last few decades, nosocomial infections caused by CoNS as opportunistic pathogens have increased and become one of the major nosocomial pathogens. The aim of this study was to identify the relationship between the use of an antibiotic agent for CoNS in Bali’s regional public hospital and the development of antibiotic resistance during 3 years period. This study was a retrospective ecological study of antibiotic resistance and antibiotic consumption secondary data collected prospectively. It was conducted over a three years period of inpatient data. Susceptibility of CoNS to antibiotics was obtained from the hospital antibiogram of all isolates from 2017 to 2019. Sensitivity results in antibiogram were based on the standards provided by the Clinical and Laboratory Standards Institute (CLSI) with the disk diffusion method. Antibiotic consumption in DDDs/100 bed-days. The relationships between DDDs/100 bed-days of each antibiotic and rates of antibiotic resistance of each resistant strain of CoNS were tested using Spearman correlation and logistic regression. There was no significant correlation between antibiotic consumption (DDD) and the percentage of antibiotic resistance among the three CoNS species (p>0.05). However, this study found there was an inverse relationship between DDD and antibiotic resistance in Staphylococcus hominis species (OR = 0.063; CI [0.004-0.915]; p=0.043). We conclude that no significant correlation between antibiotic consumption and antibiotic resistance of the 3 CoNS species. There needs to be further research to identify antibiotic consumption, antibiotic resistance and other factors affecting antibiotic resistance.Herleeyana MeriyaniDwi Arymbhi SanjayaKetut Agus AdriantaUniversitas Gadjah Madaarticleantibiotic consumption, antibiotic resistance, ecological study, consPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 251-257 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic consumption, antibiotic resistance, ecological study, cons Pharmacy and materia medica RS1-441
spellingShingle	antibiotic consumption, antibiotic resistance, ecological study, cons Pharmacy and materia medica RS1-441 Herleeyana Meriyani Dwi Arymbhi Sanjaya Ketut Agus Adrianta Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study
description	A group of coagulase-negative staphylococci (CoNS) was historically classified as a nonpathogenic bacteria. Over the last few decades, nosocomial infections caused by CoNS as opportunistic pathogens have increased and become one of the major nosocomial pathogens. The aim of this study was to identify the relationship between the use of an antibiotic agent for CoNS in Bali’s regional public hospital and the development of antibiotic resistance during 3 years period. This study was a retrospective ecological study of antibiotic resistance and antibiotic consumption secondary data collected prospectively. It was conducted over a three years period of inpatient data. Susceptibility of CoNS to antibiotics was obtained from the hospital antibiogram of all isolates from 2017 to 2019. Sensitivity results in antibiogram were based on the standards provided by the Clinical and Laboratory Standards Institute (CLSI) with the disk diffusion method. Antibiotic consumption in DDDs/100 bed-days. The relationships between DDDs/100 bed-days of each antibiotic and rates of antibiotic resistance of each resistant strain of CoNS were tested using Spearman correlation and logistic regression. There was no significant correlation between antibiotic consumption (DDD) and the percentage of antibiotic resistance among the three CoNS species (p>0.05). However, this study found there was an inverse relationship between DDD and antibiotic resistance in Staphylococcus hominis species (OR = 0.063; CI [0.004-0.915]; p=0.043). We conclude that no significant correlation between antibiotic consumption and antibiotic resistance of the 3 CoNS species. There needs to be further research to identify antibiotic consumption, antibiotic resistance and other factors affecting antibiotic resistance.
format	article
author	Herleeyana Meriyani Dwi Arymbhi Sanjaya Ketut Agus Adrianta
author_facet	Herleeyana Meriyani Dwi Arymbhi Sanjaya Ketut Agus Adrianta
author_sort	Herleeyana Meriyani
title	Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study
title_short	Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study
title_full	Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study
title_fullStr	Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study
title_full_unstemmed	Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study
title_sort	antibiotic consumption and resistance pattern of 3 coagulase-negative staphylococci species: an ecological study
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/70924e356cd34a9fbb0dc01a6512ac4e
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Antibiotic Consumption and Resistance Pattern of 3 Coagulase-Negative Staphylococci Species: An Ecological Study

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