Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development

Type 2 diabetes mellitus (DM) is a global epidemic associated with severe vascular complications development. Diabetic neuropathy is the most common chronic complication of DM that worsens patients’ life quality and prognosis. Therefore, studies dealing with DM and diabetic neuropathy unde...

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Autores principales:	Anna P. Stepanova, Tatiana L. Karonova, Anna A. Bystrova, Vadim B. Bregovsky
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	diabetes mellitus diabetic neuropathy 25(oh)d vitamin d deficiency Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/7094c4dec6ac45c0b42657ca2ba528e4
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spelling	oai:doaj.org-article:7094c4dec6ac45c0b42657ca2ba528e42021-11-14T09:00:21ZRole of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development2072-03512072-037810.14341/DM9583https://doaj.org/article/7094c4dec6ac45c0b42657ca2ba528e42018-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9583https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Type 2 diabetes mellitus (DM) is a global epidemic associated with severe vascular complications development. Diabetic neuropathy is the most common chronic complication of DM that worsens patients’ life quality and prognosis. Therefore, studies dealing with DM and diabetic neuropathy underlying mechanisms are extremely relevant. The review discusses current views on vitamin D role in glucose metabolism and inflammatory processes. It is reported that vitamin D deficiency can contribute to insulin resistance development, and change in vitamin D receptor activity or extra- and intracellular calcium concentration due to vitamin D deficiency can affect pancreatic β-cells function and lead to decrease in insulin production. Key pathogenic mechanisms of diabetic neuropathy as well as possible relationship between vitamin D deficiency and neuropathy development are in focus of this review. Results of recent clinical trials regarding vitamin D supplementation in patients with DM are also discussed. The presented data suggest that vitamin D deficiency can be considered as a non-classical risk factor for the development of not only DM but its complications as well.Anna P. StepanovaTatiana L. KaronovaAnna A. BystrovaVadim B. BregovskyEndocrinology Research Centrearticlediabetes mellitusdiabetic neuropathy25(oh)dvitamin d deficiencyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 4, Pp 301-306 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus diabetic neuropathy 25(oh)d vitamin d deficiency Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus diabetic neuropathy 25(oh)d vitamin d deficiency Nutritional diseases. Deficiency diseases RC620-627 Anna P. Stepanova Tatiana L. Karonova Anna A. Bystrova Vadim B. Bregovsky Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
description	Type 2 diabetes mellitus (DM) is a global epidemic associated with severe vascular complications development. Diabetic neuropathy is the most common chronic complication of DM that worsens patients’ life quality and prognosis. Therefore, studies dealing with DM and diabetic neuropathy underlying mechanisms are extremely relevant. The review discusses current views on vitamin D role in glucose metabolism and inflammatory processes. It is reported that vitamin D deficiency can contribute to insulin resistance development, and change in vitamin D receptor activity or extra- and intracellular calcium concentration due to vitamin D deficiency can affect pancreatic β-cells function and lead to decrease in insulin production. Key pathogenic mechanisms of diabetic neuropathy as well as possible relationship between vitamin D deficiency and neuropathy development are in focus of this review. Results of recent clinical trials regarding vitamin D supplementation in patients with DM are also discussed. The presented data suggest that vitamin D deficiency can be considered as a non-classical risk factor for the development of not only DM but its complications as well.
format	article
author	Anna P. Stepanova Tatiana L. Karonova Anna A. Bystrova Vadim B. Bregovsky
author_facet	Anna P. Stepanova Tatiana L. Karonova Anna A. Bystrova Vadim B. Bregovsky
author_sort	Anna P. Stepanova
title	Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
title_short	Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
title_full	Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
title_fullStr	Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
title_full_unstemmed	Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
title_sort	role of vitamin d deficiency in type 2 diabetes mellitus and diabetic neuropathy development
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/7094c4dec6ac45c0b42657ca2ba528e4
work_keys_str_mv	AT annapstepanova roleofvitaminddeficiencyintype2diabetesmellitusanddiabeticneuropathydevelopment AT tatianalkaronova roleofvitaminddeficiencyintype2diabetesmellitusanddiabeticneuropathydevelopment AT annaabystrova roleofvitaminddeficiencyintype2diabetesmellitusanddiabeticneuropathydevelopment AT vadimbbregovsky roleofvitaminddeficiencyintype2diabetesmellitusanddiabeticneuropathydevelopment
_version_	1718429537480474624

Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development

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