Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment

Canine monocytic ehrlichiosis (CME) is a tick-borne disease of worldwide distribution. The major causative agent is Ehrlichia canis, a gram-negative, obligate intracellular, pleomorphic bacterium of the genus Ehrlichia, which infects monocytes, macrophages and lymphocytes, forming intracytoplasmic,...

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Autores principales:	Mylonakis Mathios E., Theodorou Konstantina N.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	ehrlichia canis canine dog tick-borne diseases Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/709600270dd344d58a0d367cc7f2ac51
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spelling	oai:doaj.org-article:709600270dd344d58a0d367cc7f2ac512021-11-17T21:27:51ZCanine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment1820-744810.1515/acve-2017-0025https://doaj.org/article/709600270dd344d58a0d367cc7f2ac512017-09-01T00:00:00Zhttps://doi.org/10.1515/acve-2017-0025https://doaj.org/toc/1820-7448Canine monocytic ehrlichiosis (CME) is a tick-borne disease of worldwide distribution. The major causative agent is Ehrlichia canis, a gram-negative, obligate intracellular, pleomorphic bacterium of the genus Ehrlichia, which infects monocytes, macrophages and lymphocytes, forming intracytoplasmic, membrane-bound bacterial aggregates, called morulae. After an incubation period of 8-20 days, the course of E. canis infection, can be sequentially divided into acute, subclinical and chronic phases, although these phases can hardly be distinguished in the clinical setting. Clinical recovery is the typical outcome of acutely infected dogs, entering the subclinical phase, during which they show no or minimal clinical signs and/or mild hematological abnormalities. Immunocompetent dogs may eliminate the infection during the acute or subclinical phases, but an unpredictable proportion of dogs will eventually develop the chronic phase, characterized by aplastic pancytopenia and high mortality, due to septicemia and/or severe bleeding. This article outlines briefly the pathogenesis of CME due to E. canis, and more thoroughly reviews the recent scientific literature pertaining to the diagnosis and treatment of this devastating disease.Mylonakis Mathios E.Theodorou Konstantina N.Sciendoarticleehrlichia caniscaninedogtick-borne diseasesVeterinary medicineSF600-1100ENActa Veterinaria, Vol 67, Iss 3, Pp 299-317 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	ehrlichia canis canine dog tick-borne diseases Veterinary medicine SF600-1100
spellingShingle	ehrlichia canis canine dog tick-borne diseases Veterinary medicine SF600-1100 Mylonakis Mathios E. Theodorou Konstantina N. Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment
description	Canine monocytic ehrlichiosis (CME) is a tick-borne disease of worldwide distribution. The major causative agent is Ehrlichia canis, a gram-negative, obligate intracellular, pleomorphic bacterium of the genus Ehrlichia, which infects monocytes, macrophages and lymphocytes, forming intracytoplasmic, membrane-bound bacterial aggregates, called morulae. After an incubation period of 8-20 days, the course of E. canis infection, can be sequentially divided into acute, subclinical and chronic phases, although these phases can hardly be distinguished in the clinical setting. Clinical recovery is the typical outcome of acutely infected dogs, entering the subclinical phase, during which they show no or minimal clinical signs and/or mild hematological abnormalities. Immunocompetent dogs may eliminate the infection during the acute or subclinical phases, but an unpredictable proportion of dogs will eventually develop the chronic phase, characterized by aplastic pancytopenia and high mortality, due to septicemia and/or severe bleeding. This article outlines briefly the pathogenesis of CME due to E. canis, and more thoroughly reviews the recent scientific literature pertaining to the diagnosis and treatment of this devastating disease.
format	article
author	Mylonakis Mathios E. Theodorou Konstantina N.
author_facet	Mylonakis Mathios E. Theodorou Konstantina N.
author_sort	Mylonakis Mathios E.
title	Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment
title_short	Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment
title_full	Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment
title_fullStr	Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment
title_full_unstemmed	Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment
title_sort	canine monocytic ehrlichiosis: an update on diagnosis and treatment
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/709600270dd344d58a0d367cc7f2ac51
work_keys_str_mv	AT mylonakismathiose caninemonocyticehrlichiosisanupdateondiagnosisandtreatment AT theodoroukonstantinan caninemonocyticehrlichiosisanupdateondiagnosisandtreatment
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Canine Monocytic Ehrlichiosis: An Update on Diagnosis and Treatment

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