Assessing methods for assigning SNPs to genes in gene-based tests of association using common variants.

Assessing methods for assigning SNPs to genes in gene-based tests of association using common variants.

Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alternative to single-marker tests. In this analysis we conduct a variety of simulation studies applied to five popular gene-based tests investigating general trends related to their performance in realistic situ...

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Autores principales: Ashley Petersen, Carolina Alvarez, Scott DeClaire, Nathan L Tintle
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/709914c73ad649c48d9e2733da3eb768
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