Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase

Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a structural mechanism for kinase domain activation...

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Autores principales:	Oskar Berntsson, Ralph P. Diensthuber, Matthijs R. Panman, Alexander Björling, Emil Gustavsson, Maria Hoernke, Ashley J. Hughes, Léocadie Henry, Stephan Niebling, Heikki Takala, Janne A. Ihalainen, Gemma Newby, Silke Kerruth, Joachim Heberle, Marianne Liebi, Andreas Menzel, Robert Henning, Irina Kosheleva, Andreas Möglich, Sebastian Westenhoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/709b281f1d2d49dab68fadc575667aba
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spelling	oai:doaj.org-article:709b281f1d2d49dab68fadc575667aba2021-12-02T13:24:15ZSequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase10.1038/s41467-017-00300-52041-1723https://doaj.org/article/709b281f1d2d49dab68fadc575667aba2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00300-5https://doaj.org/toc/2041-1723Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a structural mechanism for kinase domain activation in SHK.Oskar BerntssonRalph P. DiensthuberMatthijs R. PanmanAlexander BjörlingEmil GustavssonMaria HoernkeAshley J. HughesLéocadie HenryStephan NieblingHeikki TakalaJanne A. IhalainenGemma NewbySilke KerruthJoachim HeberleMarianne LiebiAndreas MenzelRobert HenningIrina KoshelevaAndreas MöglichSebastian WestenhoffNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oskar Berntsson Ralph P. Diensthuber Matthijs R. Panman Alexander Björling Emil Gustavsson Maria Hoernke Ashley J. Hughes Léocadie Henry Stephan Niebling Heikki Takala Janne A. Ihalainen Gemma Newby Silke Kerruth Joachim Heberle Marianne Liebi Andreas Menzel Robert Henning Irina Kosheleva Andreas Möglich Sebastian Westenhoff Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
description	Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a structural mechanism for kinase domain activation in SHK.
format	article
author	Oskar Berntsson Ralph P. Diensthuber Matthijs R. Panman Alexander Björling Emil Gustavsson Maria Hoernke Ashley J. Hughes Léocadie Henry Stephan Niebling Heikki Takala Janne A. Ihalainen Gemma Newby Silke Kerruth Joachim Heberle Marianne Liebi Andreas Menzel Robert Henning Irina Kosheleva Andreas Möglich Sebastian Westenhoff
author_facet	Oskar Berntsson Ralph P. Diensthuber Matthijs R. Panman Alexander Björling Emil Gustavsson Maria Hoernke Ashley J. Hughes Léocadie Henry Stephan Niebling Heikki Takala Janne A. Ihalainen Gemma Newby Silke Kerruth Joachim Heberle Marianne Liebi Andreas Menzel Robert Henning Irina Kosheleva Andreas Möglich Sebastian Westenhoff
author_sort	Oskar Berntsson
title	Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
title_short	Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
title_full	Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
title_fullStr	Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
title_full_unstemmed	Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
title_sort	sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/709b281f1d2d49dab68fadc575667aba
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Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase

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