Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenet...

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Autores principales: Joonbeom Bae, Sang-Pil Choi, Kyoichi Isono, Ji Yoon Lee, Si-Won Park, Chang-Yong Choi, Jihye Han, Sang-Hoon Kim, Han-Hyoung Lee, Kyungmin Park, Hyun Yong Jin, Suk Jun Lee, Chung-Gyu Park, Haruhiko Koseki, Young Sik Lee, Taehoon Chun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/709e1a6df03a4c578791ba94c2bee731
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Sumario:Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenetic marks.

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