Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenet...

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Autores principales:	Joonbeom Bae, Sang-Pil Choi, Kyoichi Isono, Ji Yoon Lee, Si-Won Park, Chang-Yong Choi, Jihye Han, Sang-Hoon Kim, Han-Hyoung Lee, Kyungmin Park, Hyun Yong Jin, Suk Jun Lee, Chung-Gyu Park, Haruhiko Koseki, Young Sik Lee, Taehoon Chun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/709e1a6df03a4c578791ba94c2bee731
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:709e1a6df03a4c578791ba94c2bee7312021-12-02T16:58:16ZPhc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression10.1038/s41467-019-11386-42041-1723https://doaj.org/article/709e1a6df03a4c578791ba94c2bee7312019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11386-4https://doaj.org/toc/2041-1723Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenetic marks.Joonbeom BaeSang-Pil ChoiKyoichi IsonoJi Yoon LeeSi-Won ParkChang-Yong ChoiJihye HanSang-Hoon KimHan-Hyoung LeeKyungmin ParkHyun Yong JinSuk Jun LeeChung-Gyu ParkHaruhiko KosekiYoung Sik LeeTaehoon ChunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joonbeom Bae Sang-Pil Choi Kyoichi Isono Ji Yoon Lee Si-Won Park Chang-Yong Choi Jihye Han Sang-Hoon Kim Han-Hyoung Lee Kyungmin Park Hyun Yong Jin Suk Jun Lee Chung-Gyu Park Haruhiko Koseki Young Sik Lee Taehoon Chun Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
description	Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenetic marks.
format	article
author	Joonbeom Bae Sang-Pil Choi Kyoichi Isono Ji Yoon Lee Si-Won Park Chang-Yong Choi Jihye Han Sang-Hoon Kim Han-Hyoung Lee Kyungmin Park Hyun Yong Jin Suk Jun Lee Chung-Gyu Park Haruhiko Koseki Young Sik Lee Taehoon Chun
author_facet	Joonbeom Bae Sang-Pil Choi Kyoichi Isono Ji Yoon Lee Si-Won Park Chang-Yong Choi Jihye Han Sang-Hoon Kim Han-Hyoung Lee Kyungmin Park Hyun Yong Jin Suk Jun Lee Chung-Gyu Park Haruhiko Koseki Young Sik Lee Taehoon Chun
author_sort	Joonbeom Bae
title	Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
title_short	Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
title_full	Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
title_fullStr	Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
title_full_unstemmed	Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
title_sort	phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing vcam1 expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/709e1a6df03a4c578791ba94c2bee731
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_version_	1718382334905942016

Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

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