Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage

Abstract Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation. Prevention and early intervention...

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Autores principales:	Lizhong Sun, Libang He, Wei Wu, Li Luo, Mingyue Han, Yifang Liu, Shijie Shi, Kaijing Zhong, Jiaojiao Yang, Jiyao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/709eaf55edb2496bba415d3bdcf24386
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spelling	oai:doaj.org-article:709eaf55edb2496bba415d3bdcf243862021-11-21T12:06:36ZFibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage10.1038/s41368-021-00144-21674-28182049-3169https://doaj.org/article/709eaf55edb2496bba415d3bdcf243862021-11-01T00:00:00Zhttps://doi.org/10.1038/s41368-021-00144-2https://doaj.org/toc/1674-2818https://doaj.org/toc/2049-3169Abstract Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation. Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function, but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions. In this study, we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation (early pulpitis as the model) with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo. Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide (E. coli LPS) with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways. Moreover, nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects, attenuating inflammatory conditions in the early stage. Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage, which widens the potential cell types for inflammation regulation.Lizhong SunLibang HeWei WuLi LuoMingyue HanYifang LiuShijie ShiKaijing ZhongJiaojiao YangJiyao LiNature Publishing GrouparticleDentistryRK1-715ENInternational Journal of Oral Science, Vol 13, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dentistry RK1-715
spellingShingle	Dentistry RK1-715 Lizhong Sun Libang He Wei Wu Li Luo Mingyue Han Yifang Liu Shijie Shi Kaijing Zhong Jiaojiao Yang Jiyao Li Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
description	Abstract Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation. Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function, but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions. In this study, we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation (early pulpitis as the model) with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo. Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide (E. coli LPS) with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways. Moreover, nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects, attenuating inflammatory conditions in the early stage. Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage, which widens the potential cell types for inflammation regulation.
format	article
author	Lizhong Sun Libang He Wei Wu Li Luo Mingyue Han Yifang Liu Shijie Shi Kaijing Zhong Jiaojiao Yang Jiyao Li
author_facet	Lizhong Sun Libang He Wei Wu Li Luo Mingyue Han Yifang Liu Shijie Shi Kaijing Zhong Jiaojiao Yang Jiyao Li
author_sort	Lizhong Sun
title	Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
title_short	Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
title_full	Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
title_fullStr	Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
title_full_unstemmed	Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
title_sort	fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/709eaf55edb2496bba415d3bdcf24386
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Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage

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