Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

STAT3 is an attractive therapeutic target but its homology with other STAT proteins complicates the development of selective inhibitors. Here, the authors develop monobodies with high affinity and selectivity for STAT3 and show that they can interfere with cellular STAT3 activity.

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Autores principales:	Grégory La Sala, Camille Michiels, Tim Kükenshöner, Tania Brandstoetter, Barbara Maurer, Akiko Koide, Kelvin Lau, Florence Pojer, Shohei Koide, Veronika Sexl, Laure Dumoutier, Oliver Hantschel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/709f9a713ee849dc860cc5c099ffede8
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spelling	oai:doaj.org-article:709f9a713ee849dc860cc5c099ffede82021-12-02T15:10:51ZSelective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains10.1038/s41467-020-17920-z2041-1723https://doaj.org/article/709f9a713ee849dc860cc5c099ffede82020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17920-zhttps://doaj.org/toc/2041-1723STAT3 is an attractive therapeutic target but its homology with other STAT proteins complicates the development of selective inhibitors. Here, the authors develop monobodies with high affinity and selectivity for STAT3 and show that they can interfere with cellular STAT3 activity.Grégory La SalaCamille MichielsTim KükenshönerTania BrandstoetterBarbara MaurerAkiko KoideKelvin LauFlorence PojerShohei KoideVeronika SexlLaure DumoutierOliver HantschelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grégory La Sala Camille Michiels Tim Kükenshöner Tania Brandstoetter Barbara Maurer Akiko Koide Kelvin Lau Florence Pojer Shohei Koide Veronika Sexl Laure Dumoutier Oliver Hantschel Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
description	STAT3 is an attractive therapeutic target but its homology with other STAT proteins complicates the development of selective inhibitors. Here, the authors develop monobodies with high affinity and selectivity for STAT3 and show that they can interfere with cellular STAT3 activity.
format	article
author	Grégory La Sala Camille Michiels Tim Kükenshöner Tania Brandstoetter Barbara Maurer Akiko Koide Kelvin Lau Florence Pojer Shohei Koide Veronika Sexl Laure Dumoutier Oliver Hantschel
author_facet	Grégory La Sala Camille Michiels Tim Kükenshöner Tania Brandstoetter Barbara Maurer Akiko Koide Kelvin Lau Florence Pojer Shohei Koide Veronika Sexl Laure Dumoutier Oliver Hantschel
author_sort	Grégory La Sala
title	Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
title_short	Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
title_full	Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
title_fullStr	Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
title_full_unstemmed	Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
title_sort	selective inhibition of stat3 signaling using monobodies targeting the coiled-coil and n-terminal domains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/709f9a713ee849dc860cc5c099ffede8
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Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

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